Restoration of Corneal Transparency by Mesenchymal Stem Cells.
Stem Cell Reports
; 7(4): 583-590, 2016 10 11.
Article
en En
| MEDLINE
| ID: mdl-27693426
ABSTRACT
Transparency of the cornea is indispensable for optimal vision. Ocular trauma is a leading cause of corneal opacity, leading to 25 million cases of blindness annually. Recently, mesenchymal stem cells (MSCs) have gained prominence due to their inflammation-suppressing and tissue repair functions. Here, we investigate the potential of MSCs to restore corneal transparency following ocular injury. Using an in vivo mouse model of ocular injury, we report that MSCs have the capacity to restore corneal transparency by secreting high levels of hepatocyte growth factor (HGF). Interestingly, our data also show that HGF alone can restore corneal transparency, an observation that has translational implications for the development of HGF-based therapy.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Regeneración
/
Córnea
/
Células Madre Mesenquimatosas
Tipo de estudio:
Prognostic_studies
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Stem Cell Reports
Año:
2016
Tipo del documento:
Article
País de afiliación:
Estados Unidos