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Assessment of a multi-layered diffuse correlation spectroscopy method for monitoring cerebral blood flow in adults.
Verdecchia, Kyle; Diop, Mamadou; Lee, Albert; Morrison, Laura B; Lee, Ting-Yim; St Lawrence, Keith.
Afiliación
  • Verdecchia K; Imaging Program, Lawson Health Research Institute, London, Ontario N6A 4V2, Canada; Department of Medical Biophysics, University of Western Ontario, London, Ontario N6A 3K7, Canada.
  • Diop M; Imaging Program, Lawson Health Research Institute, London, Ontario N6A 4V2, Canada; Department of Medical Biophysics, University of Western Ontario, London, Ontario N6A 3K7, Canada.
  • Lee A; Department of Medical Biophysics, University of Western Ontario, London, Ontario N6A 3K7, Canada.
  • Morrison LB; Imaging Program, Lawson Health Research Institute, London, Ontario N6A 4V2, Canada; Department of Medical Biophysics, University of Western Ontario, London, Ontario N6A 3K7, Canada.
  • Lee TY; Imaging Program, Lawson Health Research Institute, London, Ontario N6A 4V2, Canada; Department of Medical Biophysics, University of Western Ontario, London, Ontario N6A 3K7, Canada; Imaging Research Laboratories, Robarts Research Institute, London, Ontario N6G 2V4, Canada.
  • St Lawrence K; Imaging Program, Lawson Health Research Institute, London, Ontario N6A 4V2, Canada; Department of Medical Biophysics, University of Western Ontario, London, Ontario N6A 3K7, Canada.
Biomed Opt Express ; 7(9): 3659-3674, 2016 Sep 01.
Article en En | MEDLINE | ID: mdl-27699127
Diffuse correlation spectroscopy (DCS) is a promising technique for brain monitoring as it can provide a continuous signal that is directly related to cerebral blood flow (CBF); however, signal contamination from extracerebral tissue can cause flow underestimations. The goal of this study was to investigate whether a multi-layered (ML) model that accounts for light propagation through the different tissue layers could successfully separate scalp and brain flow when applied to DCS data acquired at multiple source-detector distances. The method was first validated with phantom experiments. Next, experiments were conducted in a pig model of the adult head with a mean extracerebral tissue thickness of 9.8 ± 0.4 mm. Reductions in CBF were measured by ML DCS and computed tomography perfusion for validation; excellent agreement was observed by a mean difference of 1.2 ± 4.6% (CI95%: -31.1 and 28.6) between the two modalities, which was not significantly different.
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Texto completo: 1 Banco de datos: MEDLINE Idioma: En Revista: Biomed Opt Express Año: 2016 Tipo del documento: Article País de afiliación: Canadá
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Banco de datos: MEDLINE Idioma: En Revista: Biomed Opt Express Año: 2016 Tipo del documento: Article País de afiliación: Canadá