Ligand-Substitution Reactions of the Tellurium Compound AS-101 in Physiological Aqueous and Alcoholic Solutions.
Inorg Chem
; 55(21): 10847-10850, 2016 Nov 07.
Article
en En
| MEDLINE
| ID: mdl-27726342
ABSTRACT
Since its first crystallization, the aqueous structure of the tellurium-containing experimental drug AS-101 has never been studied. We show that, under the aqueous conditions in which it is administered, AS-101 is subjected to an immediate ligand-substitution reaction with water, yielding a stable hydrolyzed oxide anion product that is identified, for the first time, to be TeOCl3-. Studying the structure of AS-101 in propylene glycol (PG), an alcoholic solvent often used for the topical and oral administration of AS-101, revealed the same phenomenon of ligand-substitution reaction between the alcoholic ligands. Upon exposure to water, the PG-substituted product is also hydrolyzed to the same tellurium(IV) oxide form, TeOCl3-.
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Banco de datos:
MEDLINE
Asunto principal:
Agua
/
Adyuvantes Inmunológicos
/
Alcoholes
/
Etilenos
Límite:
Humans
Idioma:
En
Revista:
Inorg Chem
Año:
2016
Tipo del documento:
Article
País de afiliación:
Israel