Study of cases of abiraterone discontinuation due to toxicity in pre-chemotherapy after 1 year's experience.
J Oncol Pharm Pract
; 23(8): 615-619, 2017 Dec.
Article
en En
| MEDLINE
| ID: mdl-27753628
ABSTRACT
Abiraterone acetate is a potent and irreversible inhibitor of cytochrome p450 17A1 that suppresses androgen synthesis. It is approved for chemotherapy-naive and docetaxel-treated patients with metastatic castration-resistant prostate cancer. We describe the protocol for use of abiraterone in metastatic castration-resistant prostate cancer chemotherapy naive patients has been implanted in our centre and we review the cases of those patients whose adverse effects have forced the discontinuation of treatment. The side effects fit the safety profile of abiraterone, speed of their appearance and severity indicate that you should perform a thorough follow-up of these patients especially in the early phases of treatment.
Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Retirada de Medicamento por Seguridad
/
Neoplasias de la Próstata Resistentes a la Castración
/
Androstenos
Tipo de estudio:
Guideline
Límite:
Aged80
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
J Oncol Pharm Pract
Asunto de la revista:
FARMACIA
Año:
2017
Tipo del documento:
Article
País de afiliación:
España