In vivo evaluation of supersaturation/precipitation/re-dissolution behavior of cinnarizine, a lipophilic weak base, in the gastrointestinal tract: the key process of oral absorption.

Tanaka, Yusuke; Kawakami, Ayaka; Nanimatsu, Ami; Horio, Misaki; Matsuoka, Jumpei; Wada, Takami; Kasaoka, Satoshi; Yoshikawa, Hiroshi

Tanaka, Yusuke; Kawakami, Ayaka; Nanimatsu, Ami; Horio, Misaki; Matsuoka, Jumpei; Wada, Takami; Kasaoka, Satoshi; Yoshikawa, Hiroshi.

Afiliación

Tanaka Y; Laboratory of Pharmaceutics, Faculty of Pharmaceutical Sciences, Hiroshima International University, 5-1-1 Hiro-koshingai, Kure, Hiroshima 737-0112, Japan. Electronic address: y-tanaka@ps.hirokoku-u.ac.jp.
Kawakami A; Laboratory of Pharmaceutics, Faculty of Pharmaceutical Sciences, Hiroshima International University, 5-1-1 Hiro-koshingai, Kure, Hiroshima 737-0112, Japan.
Nanimatsu A; Laboratory of Pharmaceutics, Faculty of Pharmaceutical Sciences, Hiroshima International University, 5-1-1 Hiro-koshingai, Kure, Hiroshima 737-0112, Japan.
Horio M; Laboratory of Pharmaceutics, Faculty of Pharmaceutical Sciences, Hiroshima International University, 5-1-1 Hiro-koshingai, Kure, Hiroshima 737-0112, Japan.
Matsuoka J; Laboratory of Pharmaceutics, Faculty of Pharmaceutical Sciences, Hiroshima International University, 5-1-1 Hiro-koshingai, Kure, Hiroshima 737-0112, Japan.
Wada T; Laboratory of Pharmaceutics, Faculty of Pharmaceutical Sciences, Hiroshima International University, 5-1-1 Hiro-koshingai, Kure, Hiroshima 737-0112, Japan.
Kasaoka S; Laboratory of Pharmaceutics, Faculty of Pharmaceutical Sciences, Hiroshima International University, 5-1-1 Hiro-koshingai, Kure, Hiroshima 737-0112, Japan.
Yoshikawa H; Laboratory of Pharmaceutics, Faculty of Pharmaceutical Sciences, Hiroshima International University, 5-1-1 Hiro-koshingai, Kure, Hiroshima 737-0112, Japan.

Eur J Pharm Sci ; 96: 464-471, 2017 Jan 01.

Article en En | MEDLINE | ID: mdl-27773836

Asunto(s)

Precipitación Química; Cinarizina/administración & dosificación; Cinarizina/metabolismo; Tracto Gastrointestinal/metabolismo; Absorción Intestinal/fisiología; Administración Oral; Animales; Disponibilidad Biológica; Cinarizina/química; Evaluación Preclínica de Medicamentos/métodos; Tracto Gastrointestinal/efectos de los fármacos; Absorción Intestinal/efectos de los fármacos; Masculino; Ratas; Ratas Wistar; Solubilidad/efectos de los fármacos

Palabras clave

Lipophilic weak base; Luminal concentration; Re-dissolution; Supersaturation

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Precipitación Química / Cinarizina / Tracto Gastrointestinal / Absorción Intestinal Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Eur J Pharm Sci Asunto de la revista: FARMACIA / FARMACOLOGIA / QUIMICA Año: 2017 Tipo del documento: Article

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