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The BACE1 inhibitor verubecestat (MK-8931) reduces CNS ß-amyloid in animal models and in Alzheimer's disease patients.
Kennedy, Matthew E; Stamford, Andrew W; Chen, Xia; Cox, Kathleen; Cumming, Jared N; Dockendorf, Marissa F; Egan, Michael; Ereshefsky, Larry; Hodgson, Robert A; Hyde, Lynn A; Jhee, Stanford; Kleijn, Huub J; Kuvelkar, Reshma; Li, Wei; Mattson, Britta A; Mei, Hong; Palcza, John; Scott, Jack D; Tanen, Michael; Troyer, Matthew D; Tseng, Jack L; Stone, Julie A; Parker, Eric M; Forman, Mark S.
Afiliación
  • Kennedy ME; Department of Neuroscience, Merck Research Laboratories, Kenilworth, NJ 07033, USA. matthew.kennedy@merck.com andy.stamford1@gmail.com ericmcparker@comcast.net mark.forman@merck.com.
  • Stamford AW; Department of Global Chemistry, Merck Research Laboratories, Kenilworth, NJ 07033, USA. matthew.kennedy@merck.com andy.stamford1@gmail.com ericmcparker@comcast.net mark.forman@merck.com.
  • Chen X; Department of Neuroscience, Merck Research Laboratories, Kenilworth, NJ 07033, USA.
  • Cox K; Department of Pharmacokinetics, Pharmacodynamics and Drug Metabolism, Merck Research Laboratories, Kenilworth, NJ 07033, USA.
  • Cumming JN; Department of Global Chemistry, Merck Research Laboratories, Kenilworth, NJ 07033, USA.
  • Dockendorf MF; Department of Pharmacokinetics, Pharmacodynamics and Drug Metabolism, Merck Research Laboratories, Kenilworth, NJ 07033, USA.
  • Egan M; Department of Clinical Research, Merck Research Laboratories, Kenilworth, NJ 07033, USA.
  • Ereshefsky L; PAREXEL, Glendale, CA 91206, USA.
  • Hodgson RA; Department of Neuroscience, Merck Research Laboratories, Kenilworth, NJ 07033, USA.
  • Hyde LA; Department of Neuroscience, Merck Research Laboratories, Kenilworth, NJ 07033, USA.
  • Jhee S; PAREXEL, Glendale, CA 91206, USA.
  • Kleijn HJ; Department of Pharmacokinetics, Pharmacodynamics and Drug Metabolism, Merck Research Laboratories, Kenilworth, NJ 07033, USA.
  • Kuvelkar R; Department of Neuroscience, Merck Research Laboratories, Kenilworth, NJ 07033, USA.
  • Li W; Department of Global Chemistry, Merck Research Laboratories, Kenilworth, NJ 07033, USA.
  • Mattson BA; Department of Safety Assessment, Merck Research Laboratories, West Point, PA 19446, USA.
  • Mei H; Department of Pharmacokinetics, Pharmacodynamics and Drug Metabolism, Merck Research Laboratories, Kenilworth, NJ 07033, USA.
  • Palcza J; Department of Biostatistics, Merck Research Laboratories, Kenilworth, NJ 07033, USA.
  • Scott JD; Department of Global Chemistry, Merck Research Laboratories, Kenilworth, NJ 07033, USA.
  • Tanen M; Translational Biomarkers Department, Merck Research Laboratories, Kenilworth, NJ 07033, USA.
  • Troyer MD; Department of Translational Medicine, Merck Research Laboratories, Kenilworth, NJ 07033, USA.
  • Tseng JL; Department of Translational Medicine, Merck Research Laboratories, Kenilworth, NJ 07033, USA.
  • Stone JA; Department of Pharmacokinetics, Pharmacodynamics and Drug Metabolism, Merck Research Laboratories, Kenilworth, NJ 07033, USA.
  • Parker EM; Department of Neuroscience, Merck Research Laboratories, Kenilworth, NJ 07033, USA. matthew.kennedy@merck.com andy.stamford1@gmail.com ericmcparker@comcast.net mark.forman@merck.com.
  • Forman MS; Department of Translational Medicine, Merck Research Laboratories, Kenilworth, NJ 07033, USA. matthew.kennedy@merck.com andy.stamford1@gmail.com ericmcparker@comcast.net mark.forman@merck.com.
Sci Transl Med ; 8(363): 363ra150, 2016 11 02.
Article en En | MEDLINE | ID: mdl-27807285
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Banco de datos: MEDLINE Asunto principal: Tiadiazinas / Sistema Nervioso Central / Péptidos beta-Amiloides / Ácido Aspártico Endopeptidasas / Óxidos S-Cíclicos / Secretasas de la Proteína Precursora del Amiloide / Enfermedad de Alzheimer Límite: Animals Idioma: En Revista: Sci Transl Med Asunto de la revista: CIENCIA / MEDICINA Año: 2016 Tipo del documento: Article
Buscar en Google
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PubMed Links

Banco de datos: MEDLINE Asunto principal: Tiadiazinas / Sistema Nervioso Central / Péptidos beta-Amiloides / Ácido Aspártico Endopeptidasas / Óxidos S-Cíclicos / Secretasas de la Proteína Precursora del Amiloide / Enfermedad de Alzheimer Límite: Animals Idioma: En Revista: Sci Transl Med Asunto de la revista: CIENCIA / MEDICINA Año: 2016 Tipo del documento: Article