HIV-1 Nef sequesters MHC-I intracellularly by targeting early stages of endocytosis and recycling.

Dirk, Brennan S; Pawlak, Emily N; Johnson, Aaron L; Van Nynatten, Logan R; Jacob, Rajesh A; Heit, Bryan; Dikeakos, Jimmy D

Dirk, Brennan S; Pawlak, Emily N; Johnson, Aaron L; Van Nynatten, Logan R; Jacob, Rajesh A; Heit, Bryan; Dikeakos, Jimmy D.

Afiliación

Dirk BS; Department of Microbiology and Immunology, The University of Western Ontario, Schulich School of Medicine and Dentistry, London, Ontario, Canada.
Pawlak EN; Department of Microbiology and Immunology, The University of Western Ontario, Schulich School of Medicine and Dentistry, London, Ontario, Canada.
Johnson AL; Department of Microbiology and Immunology, The University of Western Ontario, Schulich School of Medicine and Dentistry, London, Ontario, Canada.
Van Nynatten LR; Department of Microbiology and Immunology, The University of Western Ontario, Schulich School of Medicine and Dentistry, London, Ontario, Canada.
Jacob RA; Department of Microbiology and Immunology, The University of Western Ontario, Schulich School of Medicine and Dentistry, London, Ontario, Canada.
Heit B; Department of Microbiology and Immunology, The University of Western Ontario, Schulich School of Medicine and Dentistry, London, Ontario, Canada.
Dikeakos JD; Department of Microbiology and Immunology, The University of Western Ontario, Schulich School of Medicine and Dentistry, London, Ontario, Canada.

Sci Rep ; 6: 37021, 2016 11 14.

Article en En | MEDLINE | ID: mdl-27841315

Asunto(s)

Endocitosis/fisiología; VIH-1/metabolismo; Antígenos de Histocompatibilidad Clase I/metabolismo; Productos del Gen nef del Virus de la Inmunodeficiencia Humana/metabolismo; Regulación hacia Abajo; Endosomas/metabolismo; Células HEK293; Células HeLa; Antígenos de Histocompatibilidad Clase I/genética; Humanos; Microscopía Fluorescente; Unión Proteica; Productos del Gen nef del Virus de la Inmunodeficiencia Humana/genética; Proteínas de Unión al GTP rab/genética; Proteínas de Unión al GTP rab/metabolismo; Proteínas de Unión al GTP rab5/metabolismo; Red trans-Golgi/metabolismo

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Antígenos de Histocompatibilidad Clase I / VIH-1 / Endocitosis / Productos del Gen nef del Virus de la Inmunodeficiencia Humana Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: Sci Rep Año: 2016 Tipo del documento: Article País de afiliación: Canadá

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