Gastric mucosal cracked and cobblestone-like changes resulting from proton pump inhibitor use.
Dig Endosc
; 29(3): 307-313, 2017 May.
Article
en En
| MEDLINE
| ID: mdl-27859804
ABSTRACT
BACKGROUND AND AIM:
Use of proton pump inhibitors (PPI) is histologically associated with oxyntic gland dilatations. Two interesting mucosal changes are often detected endoscopically in patients who use PPI gastric cracked mucosa (GCM) and gastric cobblestone-like mucosa (GCSM). The aim of the present study was to clarify the relationship between PPI use and these mucosal changes.METHODS:
This was a single-center observational study. All successive subjects who underwent a routine esophagogastroduodenoscopy (EGD) between August and November 2014 in Hokkaido University Hospital were enrolled. Endoscopists carried out the assessment blinded to the use of PPI and checked for GCSM and GCM using original diagnostic criteria for GCM and GCSM. Subjects were divided into two groups those who used PPI (PPI group) and those who did not (control group). Endoscopic findings and backgrounds were compared between the two groups.RESULTS:
A total of 538 patients were analyzed (control group 374 patients, men/women 204/170, median age 65.2 years; PPI group 164 patients, men/women 89/75, median age 67.1 years). GCM was detected in 54 (10.0%) subjects, and GCSM was detected in 18 (3.3%) subjects. There was a significant difference in the prevalence rate of GCM between the control group (14/374, 3.7%) and the PPI group (40/164, 24.4%) (P < 0.01). GCSM was significantly more prevalent in the PPI group (15/164, 9.1%) than in the control group (3/374, 0.8%) (P < 0.01).CONCLUSION:
Novel GCM and GCSM endoscopic findings in the corpus area seem to be strongly associated with PPI use.Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Gastropatías
/
Inhibidores de la Bomba de Protones
/
Mucosa Gástrica
Tipo de estudio:
Observational_studies
/
Risk_factors_studies
Límite:
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Dig Endosc
Asunto de la revista:
DIAGNOSTICO POR IMAGEM
/
GASTROENTEROLOGIA
Año:
2017
Tipo del documento:
Article
País de afiliación:
Japón