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Using the BITOLA system to identify candidate molecules in the interaction between oral lichen planus and depression.
Zhan, Yuanbo; Zhou, Shuang; Li, Ying; Mu, Sen; Zhang, Ruijie; Song, Xuejing; Lin, Feng; Zhang, Ruimin; Zhang, Bin.
Afiliación
  • Zhan Y; Institute of Hard Tissue Development and Regeneration, The Second Affiliated Hospital of Harbin Medical University, Harbin 150001, Heilongjiang, China.
  • Zhou S; Institute of Hard Tissue Development and Regeneration, The Second Affiliated Hospital of Harbin Medical University, Harbin 150001, Heilongjiang, China.
  • Li Y; Institute of Hard Tissue Development and Regeneration, The Second Affiliated Hospital of Harbin Medical University, Harbin 150001, Heilongjiang, China.
  • Mu S; Institute of Hard Tissue Development and Regeneration, The Second Affiliated Hospital of Harbin Medical University, Harbin 150001, Heilongjiang, China.
  • Zhang R; Colleges of Bioinformatics Science and Technology, Harbin Medical University, Harbin 150086, China.
  • Song X; Department of Stomatology, The Central Hospital of Liaoyang City, Liaoyang 111000, China.
  • Lin F; Institute of Hard Tissue Development and Regeneration, The Second Affiliated Hospital of Harbin Medical University, Harbin 150001, Heilongjiang, China.
  • Zhang R; Department of Periodontology and Oral Mucosa, The Second Affiliated Hospital of Harbin Medical University, Harbin, 150086, China. Electronic address: yzzhangrm@126.com.
  • Zhang B; Institute of Hard Tissue Development and Regeneration, The Second Affiliated Hospital of Harbin Medical University, Harbin 150001, Heilongjiang, China; Heilongjiang Academy of Medical Sciences, Harbin 150001, Heilongjiang, China. Electronic address: zhangbinyzz@126.com.
Behav Brain Res ; 320: 136-142, 2017 03 01.
Article en En | MEDLINE | ID: mdl-27913255
Exacerbations of oral lichen planus (OLP) have been linked to the periods of psychological stress, anxiety and depression. The specific mechanism of the interaction is unclear. The aim of this study was to explore the candidate genes or molecules that play important roles in the interaction between OLP and depression. The BITOLA system was used to search all intermediate concepts relevant to the "Gene or Gene Product" for OLP and depression, and the gene expression data and tissue-specific gene data along with manual checking were then employed to filter the intermediate concepts. Finally, two genes (NCAM1, neural cell adhesion molecule 1; CD4, CD4 molecule) passed the follow-up inspection. By using the text mining can formulate a new hypothesis: NCAM1 and CD4 were identified as involved or potentially involved in the interaction between OLP and depression. These results offer a new clue for the experimenters and hold promise for developing innovative therapeutic strategies for these two diseases.
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Encéfalo / Antígenos CD4 / Liquen Plano Oral / Antígeno CD56 / Depresión Tipo de estudio: Guideline Límite: Female / Humans / Male Idioma: En Revista: Behav Brain Res Año: 2017 Tipo del documento: Article País de afiliación: China

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Encéfalo / Antígenos CD4 / Liquen Plano Oral / Antígeno CD56 / Depresión Tipo de estudio: Guideline Límite: Female / Humans / Male Idioma: En Revista: Behav Brain Res Año: 2017 Tipo del documento: Article País de afiliación: China