Coronary Artery Development: Progenitor Cells and Differentiation Pathways.
Annu Rev Physiol
; 79: 1-19, 2017 02 10.
Article
en En
| MEDLINE
| ID: mdl-27959616
ABSTRACT
Coronary artery disease (CAD) is the number one cause of death worldwide and involves the accumulation of plaques within the artery wall that can occlude blood flow to the heart and cause myocardial infarction. The high mortality associated with CAD makes the development of medical interventions that repair and replace diseased arteries a high priority for the cardiovascular research community. Advancements in arterial regenerative medicine could benefit from a detailed understanding of coronary artery development during embryogenesis and of how these pathways might be reignited during disease. Recent research has advanced our knowledge on how the coronary vasculature is built and revealed unexpected features of progenitor cell deployment that may have implications for organogenesis in general. Here, we highlight these recent findings and discuss how they set the stage to interrogate developmental pathways during injury and disease.
Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Células Madre
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Enfermedad de la Arteria Coronaria
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Diferenciación Celular
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Vasos Coronarios
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Organogénesis
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Annu Rev Physiol
Año:
2017
Tipo del documento:
Article