Synthesis of Succinimide-Containing Chromones, Naphthoquinones, and Xanthones under Rh(III) Catalysis: Evaluation of Anticancer Activity.
J Org Chem
; 81(24): 12416-12425, 2016 12 16.
Article
en En
| MEDLINE
| ID: mdl-27978756
ABSTRACT
The weakly coordinating ketone group directed C-H functionalizations of chromones, 1,4-naphthoquinones, and xanthones with various maleimides under rhodium(III) catalysis are described. These protocols efficiently provide a range of succinimide-containing chromones, naphthoquinones, and xanthones with excellent site selectivity and functional group compatibility. All synthetic compounds were screened for in vitro anticancer activity against human breast adenocarcinoma cell lines (MCF-7). In particular, compounds 7aa and 7ca with a naphthoquinone scaffold were found to be highly cytotoxic, with an activity competitive with anticancer agent doxorubicin.
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Banco de datos:
MEDLINE
Asunto principal:
Rodio
/
Succinimidas
/
Cromonas
/
Naftoquinonas
/
Xantonas
/
Antineoplásicos
Límite:
Humans
Idioma:
En
Revista:
J Org Chem
Año:
2016
Tipo del documento:
Article