Glycosyltransfer in mutants of putative catalytic residue Glu303 of the human ABO(H) A and B blood group glycosyltransferases GTA and GTB proceeds through a labile active site.

Blackler, Ryan J; Gagnon, Susannah M L; Polakowski, Robert; Rose, Natisha L; Zheng, Ruixiang B; Letts, James A; Johal, Asha R; Schuman, Brock; Borisova, Svetlana N; Palcic, Monica M; Evans, Stephen V

Blackler, Ryan J; Gagnon, Susannah M L; Polakowski, Robert; Rose, Natisha L; Zheng, Ruixiang B; Letts, James A; Johal, Asha R; Schuman, Brock; Borisova, Svetlana N; Palcic, Monica M; Evans, Stephen V.

Afiliación

Blackler RJ; Department of Biochemistry and Microbiology, University of Victoria, PO Box 3800, STN CSC, Victoria, BC, Canada.
Gagnon SM; Department of Biochemistry and Microbiology, University of Victoria, PO Box 3800, STN CSC, Victoria, BC, Canada.
Polakowski R; Department of Chemistry, University of Alberta, Edmonton, AB, Canada.
Rose NL; Department of Chemistry, University of Alberta, Edmonton, AB, Canada.
Zheng RB; Department of Chemistry, University of Alberta, Edmonton, AB, Canada.
Letts JA; Department of Biochemistry and Microbiology, University of Victoria, PO Box 3800, STN CSC, Victoria, BC, Canada.
Johal AR; Department of Biochemistry and Microbiology, University of Victoria, PO Box 3800, STN CSC, Victoria, BC, Canada.
Schuman B; Department of Biochemistry and Microbiology, University of Victoria, PO Box 3800, STN CSC, Victoria, BC, Canada.
Borisova SN; Department of Biochemistry and Microbiology, University of Victoria, PO Box 3800, STN CSC, Victoria, BC, Canada.
Palcic MM; Department of Biochemistry and Microbiology, University of Victoria, PO Box 3800, STN CSC, Victoria, BC, Canada.
Evans SV; Department of Chemistry, University of Alberta, Edmonton, AB, Canada.

Glycobiology ; 27(4): 370-380, 2017 04 01.

Article en En | MEDLINE | ID: mdl-27979997

Asunto(s)

Sistema del Grupo Sanguíneo ABO/genética; Antígenos de Grupos Sanguíneos/genética; Galactosiltransferasas/genética; Sistema del Grupo Sanguíneo ABO/química; Sistema del Grupo Sanguíneo ABO/inmunología; Secuencia de Aminoácidos/genética; Antígenos de Grupos Sanguíneos/química; Catálisis; Dominio Catalítico; Cristalografía por Rayos X; Galactosiltransferasas/química; Humanos; Enlace de Hidrógeno; Cinética; Mutación; Mutación Puntual; Especificidad por Sustrato

Palabras clave

X-ray crystallography; enzyme kinetics; glycosyltransferases; mechanism; retaining

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Antígenos de Grupos Sanguíneos / Sistema del Grupo Sanguíneo ABO / Galactosiltransferasas Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: Glycobiology Asunto de la revista: BIOQUIMICA Año: 2017 Tipo del documento: Article País de afiliación: Canadá

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