Exercise-induced biochemical changes and their potential influence on cancer: a scientific review.
Br J Sports Med
; 51(8): 640-644, 2017 Apr.
Article
en En
| MEDLINE
| ID: mdl-27993842
ABSTRACT
AIM:
To review and discuss the available international literature regarding the indirect and direct biochemical mechanisms that occur after exercise, which could positively, or negatively, influence oncogenic pathways.METHODS:
The PubMed, MEDLINE, Embase and Cochrane libraries were searched for papers up to July 2016 addressing biochemical changes after exercise with a particular reference to cancer. The three authors independently assessed their appropriateness for inclusion in this review based on their scientific quality and relevance.RESULTS:
168 papers were selected and categorised into indirect and direct biochemical pathways. The indirect effects included changes in vitamin D, weight reduction, sunlight exposure and improved mood. The direct effects included insulin-like growth factor, epigenetic effects on gene expression and DNA repair, vasoactive intestinal peptide, oxidative stress and antioxidant pathways, heat shock proteins, testosterone, irisin, immunity, chronic inflammation and prostaglandins, energy metabolism and insulin resistance.SUMMARY:
Exercise is one of several lifestyle factors known to lower the risk of developing cancer and is associated with lower relapse rates and better survival. This review highlights the numerous biochemical processes, which explain these potential anticancer benefits.Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Ejercicio Físico
/
Carcinogénesis
/
Neoplasias
Tipo de estudio:
Systematic_reviews
Límite:
Humans
Idioma:
En
Revista:
Br J Sports Med
Año:
2017
Tipo del documento:
Article
País de afiliación:
Reino Unido