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Exercise-induced biochemical changes and their potential influence on cancer: a scientific review.
Thomas, Robert James; Kenfield, Stacey A; Jimenez, Alfonso.
Afiliación
  • Thomas RJ; Primrose Oncology Unit, Bedford Hospital NHS Trust, Bedford, UK.
  • Kenfield SA; Department of Urology, University of California, San Francisco, California, USA.
  • Jimenez A; Centre for Applied Biological and Exercise Sciences, Faculty of Health and Life Sciences, Coventry University, Coventry, UK.
Br J Sports Med ; 51(8): 640-644, 2017 Apr.
Article en En | MEDLINE | ID: mdl-27993842
ABSTRACT

AIM:

To review and discuss the available international literature regarding the indirect and direct biochemical mechanisms that occur after exercise, which could positively, or negatively, influence oncogenic pathways.

METHODS:

The PubMed, MEDLINE, Embase and Cochrane libraries were searched for papers up to July 2016 addressing biochemical changes after exercise with a particular reference to cancer. The three authors independently assessed their appropriateness for inclusion in this review based on their scientific quality and relevance.

RESULTS:

168 papers were selected and categorised into indirect and direct biochemical pathways. The indirect effects included changes in vitamin D, weight reduction, sunlight exposure and improved mood. The direct effects included insulin-like growth factor, epigenetic effects on gene expression and DNA repair, vasoactive intestinal peptide, oxidative stress and antioxidant pathways, heat shock proteins, testosterone, irisin, immunity, chronic inflammation and prostaglandins, energy metabolism and insulin resistance.

SUMMARY:

Exercise is one of several lifestyle factors known to lower the risk of developing cancer and is associated with lower relapse rates and better survival. This review highlights the numerous biochemical processes, which explain these potential anticancer benefits.
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Ejercicio Físico / Carcinogénesis / Neoplasias Tipo de estudio: Systematic_reviews Límite: Humans Idioma: En Revista: Br J Sports Med Año: 2017 Tipo del documento: Article País de afiliación: Reino Unido

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Ejercicio Físico / Carcinogénesis / Neoplasias Tipo de estudio: Systematic_reviews Límite: Humans Idioma: En Revista: Br J Sports Med Año: 2017 Tipo del documento: Article País de afiliación: Reino Unido