Oral to subcutaneous methotrexate dose-conversion strategy in the treatment of rheumatoid arthritis.
Rheumatol Int
; 37(2): 213-218, 2017 Feb.
Article
en En
| MEDLINE
| ID: mdl-28012023
ABSTRACT
Both the American College of Rheumatology (ACR) and European League Against Rheumatism (EULAR) guidelines recommend the use of methotrexate (MTX) for the treatment of rheumatoid arthritis (RA) when there is no contraindication. While MTX is the foundation of RA therapy (Singh et al. in Arthritis Care Res 64625-639,2012), absorption saturation compromises its oral bioavailability (BA). Differences in the relative BA of oral versus subcutaneous (SC) MTX demonstrate the need for guidance on successful dose-conversion strategies. This study was designed to compare MTX PK profiles as a result of MTX administration via three different treatment administrations oral, SC MTX administered via an auto-injector (MTXAI) into the abdomen (MTXAIab) and into the thigh (MTXAIth). In this paper, we establish a dose-conversion method based on the BA of MTX from oral and SC administration. SC administration provided higher exposure of MTX than the same dose given orally. Unlike the exposure limitations of oral MTX, dose-proportional exposure was seen with SC MTX.
Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Artritis Reumatoide
/
Metotrexato
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Antirreumáticos
Tipo de estudio:
Clinical_trials
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Guideline
Límite:
Aged
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
Rheumatol Int
Año:
2017
Tipo del documento:
Article
País de afiliación:
Estados Unidos