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Low Serum Levels of Prealbumin, Retinol Binding Protein, and Retinol Are Frequent in Adult Type 1 Diabetic Patients.
Forga, Luis; Bolado, Federico; Goñi, María José; Tamayo, Ibai; Ibáñez, Berta; Prieto, Carlos.
Afiliación
  • Forga L; Department of Endocrinology and Nutrition, Complejo Hospitalario de Navarra, Instituto de Investigación Sanitaria de Navarra (IdiSNA), Calle Irunlarrea 3, Pamplona, 31008 Navarra, Spain.
  • Bolado F; Department of Digestive System, Complejo Hospitalario de Navarra, Calle Irunlarrea 3, Pamplona, 31008 Navarra, Spain.
  • Goñi MJ; Department of Endocrinology and Nutrition, Complejo Hospitalario de Navarra, Instituto de Investigación Sanitaria de Navarra (IdiSNA), Calle Irunlarrea 3, Pamplona, 31008 Navarra, Spain.
  • Tamayo I; Navarrabiomed, Fundación Miguel Servet, Calle Irunlarrea 3, Pamplona, 31008 Navarra, Spain.
  • Ibáñez B; Navarrabiomed, Fundación Miguel Servet, Red de Investigación en Servicios Sanitarios en Enfermedades Crónicas (REDISSEC), Calle Irunlarrea 3, Pamplona, 31008 Navarra, Spain.
  • Prieto C; Department of Digestive System, Complejo Hospitalario de Navarra, Calle Irunlarrea 3, Pamplona, 31008 Navarra, Spain.
J Diabetes Res ; 2016: 2532108, 2016.
Article en En | MEDLINE | ID: mdl-28018921
ABSTRACT
Aim. To determine the serum prealbumin (PA), retinol binding protein (RBP), and retinol levels in adult patients with type 1 diabetes (T1D) and to analyze some factors related to those levels. Methods. A total of 93 patients (47 women) were studied. Age, gender, BMI, duration of diabetes, chronic complications, HbA1c, lipid profile, creatinine, albumin, PA, RBP, and retinol were recorded. High and low parameter groups were compared by Mann-Whitney U and χ2 tests. Correlation between parameters was analyzed by Spearman's test. Odds of low levels were analyzed by univariate logistic regression and included in the multivariate analysis when significant. Results. 49.5%, 48.4%, and 30.1% of patients displayed serum PA, RBP, and retinol levels below normal values, respectively. A high correlation (Rho > 0.8) between PA, RBP, and retinol serum levels was found. Patients presenting low levels of any of them were predominantly women, normal-weighted, and with lower levels of triglycerides and serum creatinine. No differences in age, macrovascular complications, duration of diabetes, or HbA1c values were observed when comparing low and normal parameter groups. Conclusion. Low serum levels of PA, RBP, and retinol are frequent in T1D adult patients. This alteration is influenced by female sex and serum creatinine and triglyceride levels.
Asunto(s)

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Vitamina A / Prealbúmina / Complicaciones de la Diabetes / Diabetes Mellitus Tipo 1 / Proteínas Celulares de Unión al Retinol Límite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: J Diabetes Res Año: 2016 Tipo del documento: Article País de afiliación: España

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Vitamina A / Prealbúmina / Complicaciones de la Diabetes / Diabetes Mellitus Tipo 1 / Proteínas Celulares de Unión al Retinol Límite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: J Diabetes Res Año: 2016 Tipo del documento: Article País de afiliación: España