Selective Aryne Formation via Grob Fragmentation from the [2+2] Cycloadducts of 3-Triflyloxyarynes.
J Am Chem Soc
; 139(2): 623-626, 2017 01 18.
Article
en En
| MEDLINE
| ID: mdl-28038312
ABSTRACT
A chemoselective ring-opening protocol of the formal [2+2] cycloadducts of 3-triflyloxyarynes was developed to generate 2,3-aryne intermediate via Grob fragmentation. A variety of 1,3-di- and 1,2,3-trisubstituted arenes could be readily accessed through this [2+2] cycloaddition-2,3-aryne formation sequence. The regioselectivity in these transformations originates from the steric repulsion of the aliphatic chain.
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MEDLINE
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En
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J Am Chem Soc
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2017
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Article