The effects of DPP-4 inhibitor on hypoxia-induced apoptosis in human umbilical vein endothelial cells.

Nagamine, Akari; Hasegawa, Hiroshi; Hashimoto, Naoko; Yamada-Inagawa, Tomoko; Hirose, Masanori; Kobara, Yuka; Tadokoro, Hiroyuki; Kobayashi, Yoshio; Takano, Hiroyuki

Nagamine, Akari; Hasegawa, Hiroshi; Hashimoto, Naoko; Yamada-Inagawa, Tomoko; Hirose, Masanori; Kobara, Yuka; Tadokoro, Hiroyuki; Kobayashi, Yoshio; Takano, Hiroyuki.

Afiliación

Nagamine A; Department of Molecular Cardiovascular Pharmacology, Graduate School of Pharmaceutical Sciences, Chiba University, Chiba 260-8675, Japan.
Hasegawa H; Department of Cardiovascular Medicine, Chiba University Graduate School of Medicine, Chiba 260-8670, Japan.
Hashimoto N; Department of Molecular Cardiovascular Pharmacology, Graduate School of Pharmaceutical Sciences, Chiba University, Chiba 260-8675, Japan.
Yamada-Inagawa T; Department of Molecular Cardiovascular Pharmacology, Graduate School of Pharmaceutical Sciences, Chiba University, Chiba 260-8675, Japan.
Hirose M; Department of Cardiovascular Medicine, Chiba University Graduate School of Medicine, Chiba 260-8670, Japan.
Kobara Y; Department of Cardiovascular Medicine, Chiba University Graduate School of Medicine, Chiba 260-8670, Japan.
Tadokoro H; Department of Cardiovascular Medicine, Chiba University Graduate School of Medicine, Chiba 260-8670, Japan.
Kobayashi Y; Department of Cardiovascular Medicine, Chiba University Graduate School of Medicine, Chiba 260-8670, Japan.
Takano H; Department of Molecular Cardiovascular Pharmacology, Graduate School of Pharmaceutical Sciences, Chiba University, Chiba 260-8675, Japan. Electronic address: htakano-cib@umin.ac.jp.

J Pharmacol Sci ; 133(1): 42-48, 2017 Jan.

Article en En | MEDLINE | ID: mdl-28081947

Asunto(s)

Apoptosis/efectos de los fármacos; Hipoxia de la Célula/fisiología; Dipeptidil Peptidasa 4/biosíntesis; Inhibidores de la Dipeptidil-Peptidasa IV/farmacología; Células Endoteliales de la Vena Umbilical Humana/citología; Células Endoteliales de la Vena Umbilical Humana/efectos de los fármacos; Hipoxia de la Célula/efectos de los fármacos; Supervivencia Celular/efectos de los fármacos; Células Cultivadas; Quimiocina CXCL12/biosíntesis; Dipeptidil Peptidasa 4/metabolismo; Células Endoteliales de la Vena Umbilical Humana/metabolismo; Humanos; Oligopéptidos/farmacología; Receptores CXCR4/antagonistas & inhibidores; Factor de Transcripción STAT3/antagonistas & inhibidores; Transducción de Señal/efectos de los fármacos

Palabras clave

Apoptosis; Dipeptidyl peptidase-4; Endothelial cell; Hypoxia

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Hipoxia de la Célula / Apoptosis / Dipeptidil Peptidasa 4 / Inhibidores de la Dipeptidil-Peptidasa IV / Células Endoteliales de la Vena Umbilical Humana Límite: Humans Idioma: En Revista: J Pharmacol Sci Asunto de la revista: FARMACOLOGIA Año: 2017 Tipo del documento: Article País de afiliación: Japón

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