Increased PD-L1 expression in breast and colon cancer stem cells.
Clin Exp Pharmacol Physiol
; 44(5): 602-604, 2017 May.
Article
en En
| MEDLINE
| ID: mdl-28107571
ABSTRACT
Here we report the expression of programmed cell death ligand 1/2 (PD-L1/L2) in breast and colon cancer stem cells (CSCs). The stemness of these cells was confirmed by their surface markers. Using flow cytometry analysis we demonstrated that PD-L1 expression was higher in CSCs of both cancers compared to non-stem like cancer cells. Consistent with this, detection of cellular PD-L1 proteins by western blot assay also showed increased PD-L1 protein in CSCs. In contrast, only trace amounts of PD-L2 were detected in CSCs of both cancers. Our results suggest that breast and colon cancers may be sensitive to PD1/PD-L1 immunotherapy and thus warrant further investigations of CSC targeted PD1/PD-L1 therapy.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Células Madre Neoplásicas
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Neoplasias de la Mama
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Regulación Neoplásica de la Expresión Génica
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Neoplasias del Colon
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Antígeno B7-H1
Límite:
Female
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Humans
Idioma:
En
Revista:
Clin Exp Pharmacol Physiol
Año:
2017
Tipo del documento:
Article
País de afiliación:
Australia