Detoxification of benzo[a]pyrene primarily depends on cytochrome P450, while bioactivation involves additional oxidoreductases including 5-lipoxygenase, cyclooxygenase, and aldo-keto reductase in the liver.

Wang, Liupeng; Xu, Wenwei; Ma, Leilei; Zhang, Suxing; Zhang, Kezhi; Ye, Peizhen; Xing, Guozhen; Zhang, Xuefeng; Cao, Yiyi; Xi, Jing; Gu, Jun; Luan, Yang

Wang, Liupeng; Xu, Wenwei; Ma, Leilei; Zhang, Suxing; Zhang, Kezhi; Ye, Peizhen; Xing, Guozhen; Zhang, Xuefeng; Cao, Yiyi; Xi, Jing; Gu, Jun; Luan, Yang.

Afiliación

Wang L; Hongqiao International Institute of Medicine, Shanghai Tong Ren Hospital and Faculty of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, People's Republic of China.
Xu W; Tong Ren Hospital Affiliated To Shanghai Jiao Tong University School of Medicine, Shanghai, 200336, People's Republic of China.
Ma L; Hongqiao International Institute of Medicine, Shanghai Tong Ren Hospital and Faculty of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, People's Republic of China.
Zhang S; KG Pharma Limited, Foshan, 528000, People's Republic of China.
Zhang K; KG Pharma Limited, Foshan, 528000, People's Republic of China.
Ye P; KG Pharma Limited, Foshan, 528000, People's Republic of China.
Xing G; Jiangsu Tripod Preclinical Research Laboratories, Pukou Economic Development Zone, Nanjing, People's Republic of China.
Zhang X; Jiangsu Tripod Preclinical Research Laboratories, Pukou Economic Development Zone, Nanjing, People's Republic of China.
Cao Y; Hongqiao International Institute of Medicine, Shanghai Tong Ren Hospital and Faculty of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, People's Republic of China.
Xi J; Hongqiao International Institute of Medicine, Shanghai Tong Ren Hospital and Faculty of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, People's Republic of China.
Gu J; Wadsworth Center, New York State Department of Health, Albany, NY, 12201-0509, USA.
Luan Y; Hongqiao International Institute of Medicine, Shanghai Tong Ren Hospital and Faculty of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, People's Republic of China.

J Biochem Mol Toxicol ; 31(7)2017 Jul.

Article en En | MEDLINE | ID: mdl-28111842

Asunto(s)

Aldo-Ceto Reductasas/metabolismo; Araquidonato 5-Lipooxigenasa/metabolismo; Benzo(a)pireno/farmacocinética; Sistema Enzimático del Citocromo P-450/metabolismo; Hígado/enzimología; Aldo-Ceto Reductasas/genética; Animales; Araquidonato 5-Lipooxigenasa/genética; Benzo(a)pireno/farmacología; Sistema Enzimático del Citocromo P-450/genética; Células Madre Hematopoyéticas/enzimología; Inactivación Metabólica; Macaca fascicularis; Ratones; Ratones Noqueados

Palabras clave

benzo[a]pyrene; cytochrome P450; mutagenicity; oxidoreductase

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Benzo(a)pireno / Araquidonato 5-Lipooxigenasa / Sistema Enzimático del Citocromo P-450 / Aldo-Ceto Reductasas / Hígado Límite: Animals Idioma: En Revista: J Biochem Mol Toxicol Asunto de la revista: BIOLOGIA MOLECULAR / BIOQUIMICA / TOXICOLOGIA Año: 2017 Tipo del documento: Article

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