Tandem application of ligand-based virtual screening and G4-OAS assay to identify novel G-quadruplex-targeting chemotypes.

Musumeci, Domenica; Amato, Jussara; Zizza, Pasquale; Platella, Chiara; Cosconati, Sandro; Cingolani, Chiara; Biroccio, Annamaria; Novellino, Ettore; Randazzo, Antonio; Giancola, Concetta; Pagano, Bruno; Montesarchio, Daniela

Musumeci, Domenica; Amato, Jussara; Zizza, Pasquale; Platella, Chiara; Cosconati, Sandro; Cingolani, Chiara; Biroccio, Annamaria; Novellino, Ettore; Randazzo, Antonio; Giancola, Concetta; Pagano, Bruno; Montesarchio, Daniela.

Afiliación

Musumeci D; Department of Chemical Sciences, University of Naples Federico II, Naples 80126, Italy.
Amato J; Department of Pharmacy, University of Naples Federico II, Naples 80131, Italy.
Zizza P; Oncogenomic and Epigenetic Unit, Regina Elena National Cancer Institute, Rome 00144, Italy.
Platella C; Department of Chemical Sciences, University of Naples Federico II, Naples 80126, Italy.
Cosconati S; DiSTABiF, Second University of Naples, Caserta 81100, Italy.
Cingolani C; Oncogenomic and Epigenetic Unit, Regina Elena National Cancer Institute, Rome 00144, Italy.
Biroccio A; Oncogenomic and Epigenetic Unit, Regina Elena National Cancer Institute, Rome 00144, Italy.
Novellino E; Department of Pharmacy, University of Naples Federico II, Naples 80131, Italy.
Randazzo A; Department of Pharmacy, University of Naples Federico II, Naples 80131, Italy.
Giancola C; Department of Pharmacy, University of Naples Federico II, Naples 80131, Italy.
Pagano B; Department of Pharmacy, University of Naples Federico II, Naples 80131, Italy. Electronic address: bruno.pagano@unina.it.
Montesarchio D; Department of Chemical Sciences, University of Naples Federico II, Naples 80126, Italy. Electronic address: daniela.montesarchio@unina.it.

Biochim Biophys Acta Gen Subj ; 1861(5 Pt B): 1341-1352, 2017 May.

Article en En | MEDLINE | ID: mdl-28130159

Asunto(s)

Antineoplásicos/farmacología; ADN de Neoplasias/efectos de los fármacos; Diseño de Fármacos; G-Cuádruplex/efectos de los fármacos; Guanosina/metabolismo; Ensayos Analíticos de Alto Rendimiento; Neoplasias/tratamiento farmacológico; Telómero/efectos de los fármacos; Antineoplásicos/química; Antineoplásicos/metabolismo; Sitios de Unión; Línea Celular Transformada; Proliferación Celular/efectos de los fármacos; Supervivencia Celular/efectos de los fármacos; ADN de Neoplasias/química; ADN de Neoplasias/genética; ADN de Neoplasias/metabolismo; Relación Dosis-Respuesta a Droga; Guanosina/química; Humanos; Ligandos; Modelos Moleculares; Neoplasias/genética; Neoplasias/patología; Bibliotecas de Moléculas Pequeñas; Relación Estructura-Actividad; Telómero/química; Telómero/genética; Telómero/metabolismo; Factores de Tiempo

Palabras clave

Anticancer agents; Drug discovery; G-quadruplex; Virtual screening

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: ADN de Neoplasias / Diseño de Fármacos / Telómero / G-Cuádruplex / Ensayos Analíticos de Alto Rendimiento / Guanosina / Neoplasias / Antineoplásicos Tipo de estudio: Diagnostic_studies / Prognostic_studies / Screening_studies Límite: Humans Idioma: En Revista: Biochim Biophys Acta Gen Subj Año: 2017 Tipo del documento: Article País de afiliación: Italia

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