Antigen-Presenting Cells in the Skin.
Annu Rev Immunol
; 35: 469-499, 2017 04 26.
Article
en En
| MEDLINE
| ID: mdl-28226228
ABSTRACT
Professional antigen-presenting cells (APCs) in the skin include dendritic cells, monocytes, and macrophages. They are highly dynamic, with the capacity to enter skin from the peripheral circulation, patrol within tissue, and migrate through lymphatics to draining lymph nodes. Skin APCs are endowed with antigen-sensing, -processing, and -presenting machinery and play key roles in initiating, modulating, and resolving cutaneous inflammation. Skin APCs are a highly heterogeneous population with functionally specialized subsets that are developmentally imprinted and modulated by local tissue microenvironmental and inflammatory cues. This review explores recent advances that have allowed for a more accurate taxonomy of APC subsets found in both mouse and human skin. It also examines the functional specificity of individual APC subsets and their collaboration with other immune cell types that together promote adaptive T cell and regional cutaneous immune responses during homeostasis, inflammation, and disease.
Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Piel
/
Células Dendríticas
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Monocitos
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Linfocitos T
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Células de Langerhans
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Macrófagos
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Células Presentadoras de Antígenos
Límite:
Animals
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Humans
Idioma:
En
Revista:
Annu Rev Immunol
Año:
2017
Tipo del documento:
Article