Kinetics of nucleotide entry into RNA polymerase active site provides mechanism for efficiency and fidelity.

Wang, Beibei; Sexton, Rachel E; Feig, Michael

Wang, Beibei; Sexton, Rachel E; Feig, Michael.

Afiliación

Wang B; Department of Biochemistry & Molecular Biology, 603 Wilson Rd., Room 218 BCH, Michigan State University, East Lansing, MI 48824, USA. Electronic address: bbwang@msu.edu.
Sexton RE; Department of Biochemistry & Molecular Biology, 603 Wilson Rd., Room 218 BCH, Michigan State University, East Lansing, MI 48824, USA. Electronic address: sextonra@msu.edu.
Feig M; Department of Biochemistry & Molecular Biology, 603 Wilson Rd., Room 218 BCH, Michigan State University, East Lansing, MI 48824, USA. Electronic address: feig@msu.edu.

Biochim Biophys Acta Gene Regul Mech ; 1860(4): 482-490, 2017 Apr.

Article en En | MEDLINE | ID: mdl-28242207

Asunto(s)

Dominio Catalítico; ARN Polimerasas Dirigidas por ADN/metabolismo; Nucleótidos/metabolismo; Sitios de Unión; Cinética; Simulación de Dinámica Molecular; Saccharomyces cerevisiae/enzimología; Electricidad Estática

Palabras clave

Markov state model; Molecular dynamics simulation; NTP discrimination; Network model; Secondary pore

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: ARN Polimerasas Dirigidas por ADN / Dominio Catalítico / Nucleótidos Tipo de estudio: Prognostic_studies Idioma: En Revista: Biochim Biophys Acta Gene Regul Mech Año: 2017 Tipo del documento: Article

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