Exosomes derived from human platelet-rich plasma prevent apoptosis induced by glucocorticoid-associated endoplasmic reticulum stress in rat osteonecrosis of the femoral head via the Akt/Bad/Bcl-2 signal pathway.

Tao, Shi-Cong; Yuan, Ting; Rui, Bi-Yu; Zhu, Zhen-Zhong; Guo, Shang-Chun; Zhang, Chang-Qing

Tao, Shi-Cong; Yuan, Ting; Rui, Bi-Yu; Zhu, Zhen-Zhong; Guo, Shang-Chun; Zhang, Chang-Qing.

Afiliación

Tao SC; Department of Orthopedic Surgery, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, 600 Yishan Road, Shanghai 200233, China.
Yuan T; Department of Orthopedic Surgery, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, 600 Yishan Road, Shanghai 200233, China.
Rui BY; Department of Orthopedic Surgery, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, 600 Yishan Road, Shanghai 200233, China.
Zhu ZZ; Department of Orthopedic Surgery, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, 600 Yishan Road, Shanghai 200233, China.
Guo SC; Institute of Microsurgery on Extremities, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, 600 Yishan Road, Shanghai 200233, China.
Zhang CQ; Department of Orthopedic Surgery, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, 600 Yishan Road, Shanghai 200233, China;; Institute of Microsurgery on Extremities, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, 600 Yishan Road, Shanghai 200233, China.

Theranostics ; 7(3): 733-750, 2017.

Article en En | MEDLINE | ID: mdl-28255363

Asunto(s)

Apoptosis; Estrés del Retículo Endoplásmico; Exosomas/metabolismo; Necrosis de la Cabeza Femoral/inducido químicamente; Necrosis de la Cabeza Femoral/prevención & control; Glucocorticoides/efectos adversos; Transducción de Señal/efectos de los fármacos; Animales; Línea Celular; Supervivencia Celular/efectos de los fármacos; Modelos Animales de Enfermedad; Ratones; Osteoblastos/efectos de los fármacos; Osteoblastos/fisiología; Ratas; Resultado del Tratamiento

Palabras clave

apoptosis.; endoplasmic reticulum stress; exosomes; glucocorticoids; osteonecrosis of the femoral head; platelet-rich plasma

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Transducción de Señal / Apoptosis / Exosomas / Necrosis de la Cabeza Femoral / Estrés del Retículo Endoplásmico / Glucocorticoides Tipo de estudio: Prognostic_studies / Risk_factors_studies Límite: Animals Idioma: En Revista: Theranostics Año: 2017 Tipo del documento: Article País de afiliación: China

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