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Evaluation of anti-diabetic effect and gall bladder function with 2-thio-5-thiomethyl substituted imidazoles as TGR5 receptor agonists.
Zhang, Xuqing; Sui, Zhihua; Kauffman, Jack; Hou, Cuifen; Chen, Cailin; Du, Fuyong; Kirchner, Thomas; Liang, Yin; Johnson, Dana; Murray, William V; Demarest, Keith.
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  • Zhang X; Cardiovascular and Metabolic Research, Janssen Research & Development, LLC, Welsh & McKean Roads, Box 776, Spring House, PA 19477, United States. Electronic address: xzhang5@its.jnj.com.
  • Sui Z; Cardiovascular and Metabolic Research, Janssen Research & Development, LLC, Welsh & McKean Roads, Box 776, Spring House, PA 19477, United States.
  • Kauffman J; Cardiovascular and Metabolic Research, Janssen Research & Development, LLC, Welsh & McKean Roads, Box 776, Spring House, PA 19477, United States.
  • Hou C; Cardiovascular and Metabolic Research, Janssen Research & Development, LLC, Welsh & McKean Roads, Box 776, Spring House, PA 19477, United States.
  • Chen C; Cardiovascular and Metabolic Research, Janssen Research & Development, LLC, Welsh & McKean Roads, Box 776, Spring House, PA 19477, United States.
  • Du F; Cardiovascular and Metabolic Research, Janssen Research & Development, LLC, Welsh & McKean Roads, Box 776, Spring House, PA 19477, United States.
  • Kirchner T; Cardiovascular and Metabolic Research, Janssen Research & Development, LLC, Welsh & McKean Roads, Box 776, Spring House, PA 19477, United States.
  • Liang Y; Cardiovascular and Metabolic Research, Janssen Research & Development, LLC, Welsh & McKean Roads, Box 776, Spring House, PA 19477, United States.
  • Johnson D; Cardiovascular and Metabolic Research, Janssen Research & Development, LLC, Welsh & McKean Roads, Box 776, Spring House, PA 19477, United States.
  • Murray WV; Cardiovascular and Metabolic Research, Janssen Research & Development, LLC, Welsh & McKean Roads, Box 776, Spring House, PA 19477, United States.
  • Demarest K; Cardiovascular and Metabolic Research, Janssen Research & Development, LLC, Welsh & McKean Roads, Box 776, Spring House, PA 19477, United States.
Bioorg Med Chem Lett ; 27(8): 1760-1764, 2017 04 15.
Article en En | MEDLINE | ID: mdl-28285911
A novel series of 2-thio-5-thiomethyl substituted imidazoles was discovered to be potent TGR5 agonists that possessed glucose-lowering effects while inhibiting gall bladder emptying in mice.
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Vaciamiento Vesicular / Receptores Acoplados a Proteínas G / Diabetes Mellitus / Hipoglucemiantes / Imidazoles Límite: Animals / Humans Idioma: En Revista: Bioorg Med Chem Lett Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2017 Tipo del documento: Article
Texto completo
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Vaciamiento Vesicular / Receptores Acoplados a Proteínas G / Diabetes Mellitus / Hipoglucemiantes / Imidazoles Límite: Animals / Humans Idioma: En Revista: Bioorg Med Chem Lett Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2017 Tipo del documento: Article