[In vivo confocal microscopic observation of corneal changes in patients with chronic Stevens-Johnson syndrome or toxic epidermal necrolysis].
Zhonghua Yan Ke Za Zhi
; 53(3): 177-181, 2017 Mar 11.
Article
en Zh
| MEDLINE
| ID: mdl-28316191
ABSTRACT
Objective:
To describe corneal alterations visible on in vivo confocal microscopy in patients with debilitating ocular sequelae caused by Stevens-Johnson syndrome (SJS) or toxic epidermal necrolysis (TEN).Methods:
Twenty-two eyes of 11 consecutive patients suffering from chronic SJS or TEN were studied using slit lamp and in vivo confocal microscopy in the Ophthalmology Outpatient Department of Peking Union Medical College Hospital from March 2014 to April 2015.Results:
Dry eye with meibomian gland dysfunction (19 eyes of 10 patients, 86.4%) was the most frequent clinical sequelae. Two patients (3 eyes, 13.6%) had severe vison loss with corneal neovascularization and conjunctivization. One patient had asymmetric binocular disease. Corneal epithelial cells were observed at an active state in 10 patients (19 eyes, 86.4%) and corneal stromal cells at an active state in all patients (22 eyes, 100%). Twenty eyes (10 patients, 91%) were noted with abnormal nerve layout and 10 eyes (5 patients, 45.5%) with dendritic cell infiltration around pathological nerve damages. Numerous inflammory cells were observed in 6 eyes (3 patients, 27.3%).Conclusions:
The corneas of patients with chronic ocular sequelae associated with SJS or TEN present a number of abnormalities. In vivo confocal microscopy is a potetial useful tool for therapeutic indications and for follow-up of the debilitating chronic ocular problems linked to SJS and TEN. (Chin J Ophthalmol, 2017, 53177-181).Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Síndromes de Ojo Seco
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Síndrome de Stevens-Johnson
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Córnea
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Enfermedades de la Córnea
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Células Epiteliales
Tipo de estudio:
Diagnostic_studies
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Etiology_studies
Límite:
Female
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Humans
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Male
Idioma:
Zh
Revista:
Zhonghua Yan Ke Za Zhi
Año:
2017
Tipo del documento:
Article
País de afiliación:
China