Provision of physiological data and reference values in awake and anaesthetized female sheep aged 6-12 months.
Vet Anaesth Analg
; 44(3): 518-528, 2017 May.
Article
en En
| MEDLINE
| ID: mdl-28330726
ABSTRACT
OBJECTIVE:
To provide physiological data and reference values in awake and anaesthetized sheep aged 6-12 months. STUDYDESIGN:
Descriptive study. ANIMALS Data from 260 female sheep of the species Ovis orientalis aries aged 6-12 months were extracted from 10 experimental trials.METHODS:
Data from pulmonary arterial thermodilution in awake (cohort 1; n = 109) and anaesthetized animals (cohort 2; n = 81), and transpulmonary thermodilution in anaesthetized animals (cohort 3; n = 70) were analysed. General anaesthesia was induced by intramuscular injection of S-ketamine and midazolam and maintained by inhaled isoflurane. Standard laboratory variables (blood gas and clinical chemistry) were assessed.RESULTS:
A total of 7553 single data entries from 260 healthy sheep were included. Measurement errors or invalid data documentation meant that 313 data entries (4.1%) were excluded. A small confidence interval for median values was calculated for nearly all variables. The median body weight was 39.8 kg (2.5-97.5th percentile 30.6-48.1 kg). A set of reference values (2.5-97.5th percentiles) is provided for common cardiopulmonary and laboratory variables. Compared to awake animals, haemodynamic variables were markedly influenced by anaesthesia, as reflected by a considerably lower stroke volume index in anaesthetized sheep. There were also differences in stroke volume index between the cohorts of pulmonary artery and transpulmonary thermodilution. CONCLUSIONS AND CLINICAL RELEVANCE The present work presents a large and consistent database of a variety of physiological variables measured in healthy juvenile female sheep. The data appear to be robust and allow the establishment of standardized inclusion criteria for experimental studies and may help to better evaluate past, present and future research. Differences between pulmonary artery and transpulmonary thermodilution should be assessed in future studies.Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Vigilia
/
Peso Corporal
/
Ovinos
/
Hemodinámica
/
Anestesia
Tipo de estudio:
Prognostic_studies
Límite:
Animals
Idioma:
En
Revista:
Vet Anaesth Analg
Asunto de la revista:
ANESTESIOLOGIA
/
MEDICINA VETERINARIA
Año:
2017
Tipo del documento:
Article