The Ubiquitin Ligase CHIP Integrates Proteostasis and Aging by Regulation of Insulin Receptor Turnover.

Tawo, Riga; Pokrzywa, Wojciech; Kevei, Éva; Akyuz, Melek E; Balaji, Vishnu; Adrian, Svenja; Höhfeld, Jörg; Hoppe, Thorsten

Tawo, Riga; Pokrzywa, Wojciech; Kevei, Éva; Akyuz, Melek E; Balaji, Vishnu; Adrian, Svenja; Höhfeld, Jörg; Hoppe, Thorsten.

Afiliación

Tawo R; Institute for Cell Biology, University of Bonn, Ulrich-Haberland Str. 61a, 53121 Bonn, Germany.
Pokrzywa W; Institute for Genetics and CECAD Research Center, University of Cologne, Joseph-Stelzmann Str. 26, 50931 Cologne, Germany.
Kevei É; Institute for Genetics and CECAD Research Center, University of Cologne, Joseph-Stelzmann Str. 26, 50931 Cologne, Germany.
Akyuz ME; Institute for Genetics and CECAD Research Center, University of Cologne, Joseph-Stelzmann Str. 26, 50931 Cologne, Germany.
Balaji V; Institute for Genetics and CECAD Research Center, University of Cologne, Joseph-Stelzmann Str. 26, 50931 Cologne, Germany.
Adrian S; Institute for Cell Biology, University of Bonn, Ulrich-Haberland Str. 61a, 53121 Bonn, Germany.
Höhfeld J; Institute for Cell Biology, University of Bonn, Ulrich-Haberland Str. 61a, 53121 Bonn, Germany. Electronic address: hoehfeld@uni-bonn.de.
Hoppe T; Institute for Genetics and CECAD Research Center, University of Cologne, Joseph-Stelzmann Str. 26, 50931 Cologne, Germany. Electronic address: thorsten.hoppe@uni-koeln.de.

Cell ; 169(3): 470-482.e13, 2017 04 20.

Article en En | MEDLINE | ID: mdl-28431247

Asunto(s)

Envejecimiento; Antígenos CD/metabolismo; Receptor de Insulina/metabolismo; Ubiquitina-Proteína Ligasas/metabolismo; Animales; Caenorhabditis elegans; Drosophila melanogaster; Endocitosis; Humanos; Longevidad; Lisosomas/metabolismo; Proteolisis; Proteoma; Transducción de Señal; Somatomedinas; Ubiquitinación

Palabras clave

C. elegans; CHIP; DAF-2; Drosophila; aging; chaperone; insulin signaling; longevity; proteostasis; ubiquitin

Texto completo

Imprimir

XML

PubMed Links

Buscar en Google

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Envejecimiento / Receptor de Insulina / Antígenos CD / Ubiquitina-Proteína Ligasas Límite: Animals / Humans Idioma: En Revista: Cell Año: 2017 Tipo del documento: Article País de afiliación: Alemania

Texto completo

Imprimir

XML

PubMed Links

Buscar en Google