Impaired lysosomal activity mediated autophagic flux disruption by graphite carbon nanofibers induce apoptosis in human lung epithelial cells through oxidative stress and energetic impairment.

Mittal, Sandeep; Sharma, Pradeep Kumar; Tiwari, Ratnakar; Rayavarapu, Raja Gopal; Shankar, Jai; Chauhan, Lalit Kumar Singh; Pandey, Alok Kumar

Mittal, Sandeep; Sharma, Pradeep Kumar; Tiwari, Ratnakar; Rayavarapu, Raja Gopal; Shankar, Jai; Chauhan, Lalit Kumar Singh; Pandey, Alok Kumar.

Afiliación

Mittal S; Academy of Scientific and Innovative Research (AcSIR), CSIR-IITR Campus, Lucknow, India.
Sharma PK; Nanomaterials Toxicology Laboratory, Nanotherapeutics and Nanomaterial Toxicology Group, CSIR - Indian Institute of Toxicology Research (CSIR - IITR), Vishvigyan Bhawan, 31, Mahatma Gandhi Marg, Lucknow, 226001, Uttar Pradesh, India.
Tiwari R; Environmental Carcinogenesis Laboratory, Food, Drug and Chemical Toxicology Group, CSIR - Indian Institute of Toxicology Research (CSIR - IITR), Vishvigyan Bhawan, 31, Mahatma Gandhi Marg, Lucknow, 226001, Uttar Pradesh, India.
Rayavarapu RG; Developmental Toxicology Laboratory, System Toxicology and Health Risk Assessment Group, CSIR - Indian Institute of Toxicology Research (CSIR - IITR), Vishvigyan Bhawan, 31, Mahatma Gandhi Marg, Lucknow, 226001, Uttar Pradesh, India.
Shankar J; Academy of Scientific and Innovative Research (AcSIR), CSIR-IITR Campus, Lucknow, India.
Chauhan LKS; Nanomaterials Toxicology Laboratory, Nanotherapeutics and Nanomaterial Toxicology Group, CSIR - Indian Institute of Toxicology Research (CSIR - IITR), Vishvigyan Bhawan, 31, Mahatma Gandhi Marg, Lucknow, 226001, Uttar Pradesh, India.
Pandey AK; Electron Microscopy Laboratory, CSIR - Indian Institute of Toxicology Research (CSIR - IITR), Vishvigyan Bhawan 31, Mahatma Gandhi Marg, Lucknow, 226001, Uttar Pradesh, India.

Part Fibre Toxicol ; 14(1): 15, 2017 04 28.

Article en En | MEDLINE | ID: mdl-28454554

Asunto(s)

Apoptosis/efectos de los fármacos; Autofagia/efectos de los fármacos; Grafito/toxicidad; Lisosomas/efectos de los fármacos; Potencial de la Membrana Mitocondrial/efectos de los fármacos; Nanofibras/toxicidad; Estrés Oxidativo/efectos de los fármacos; Células A549; Supervivencia Celular/efectos de los fármacos; Células Epiteliales/efectos de los fármacos; Humanos; Pulmón/efectos de los fármacos; Tamaño de la Partícula; Especies Reactivas de Oxígeno/metabolismo; Propiedades de Superficie

Palabras clave

ATP loss; Apoptosis; Autophagy; Destabilization of lysosomes; Genotoxicity; Graphite carbon nanofibers (GCNF); Mitochondrial damage; Reactive oxygen species (ROS)

Texto completo

Imprimir

XML

PubMed Links

Buscar en Google

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Autofagia / Apoptosis / Estrés Oxidativo / Potencial de la Membrana Mitocondrial / Nanofibras / Grafito / Lisosomas Tipo de estudio: Risk_factors_studies Límite: Humans Idioma: En Revista: Part Fibre Toxicol Asunto de la revista: TOXICOLOGIA Año: 2017 Tipo del documento: Article País de afiliación: India

Texto completo

Imprimir

XML

PubMed Links

Buscar en Google