Synthesis of the Ca<sup>2+</sup>-mobilizing messengers NAADP and cADPR by intracellular CD38 enzyme in the mouse heart: Role in ß-adrenoceptor signaling.

Lin, Wee K; Bolton, Emma L; Cortopassi, Wilian A; Wang, Yanwen; O'Brien, Fiona; Maciejewska, Matylda; Jacobson, Matthew P; Garnham, Clive; Ruas, Margarida; Parrington, John; Lei, Ming; Sitsapesan, Rebecca; Galione, Antony; Terrar, Derek A

Synthesis of the Ca²⁺-mobilizing messengers NAADP and cADPR by intracellular CD38 enzyme in the mouse heart: Role in ß-adrenoceptor signaling.

Lin, Wee K; Bolton, Emma L; Cortopassi, Wilian A; Wang, Yanwen; O'Brien, Fiona; Maciejewska, Matylda; Jacobson, Matthew P; Garnham, Clive; Ruas, Margarida; Parrington, John; Lei, Ming; Sitsapesan, Rebecca; Galione, Antony; Terrar, Derek A.

Afiliación

Lin WK; From the Department of Pharmacology, University of Oxford, Mansfield Road, Oxford OX1 3QT, United Kingdom.
Bolton EL; From the Department of Pharmacology, University of Oxford, Mansfield Road, Oxford OX1 3QT, United Kingdom.
Cortopassi WA; the Department of Chemistry, Chemistry Research Laboratory, University of Oxford, Mansfield Road, Oxford OX1 3TA, United Kingdom.
Wang Y; the Department of Pharmaceutical Chemistry, University of California, San Francisco, California 94158, and.
O'Brien F; the Faculty of Biology, Medicine, and Health, University of Manchester, Manchester M13 9NT, United Kingdom.
Maciejewska M; From the Department of Pharmacology, University of Oxford, Mansfield Road, Oxford OX1 3QT, United Kingdom.
Jacobson MP; From the Department of Pharmacology, University of Oxford, Mansfield Road, Oxford OX1 3QT, United Kingdom.
Garnham C; the Department of Pharmaceutical Chemistry, University of California, San Francisco, California 94158, and.
Ruas M; From the Department of Pharmacology, University of Oxford, Mansfield Road, Oxford OX1 3QT, United Kingdom.
Parrington J; From the Department of Pharmacology, University of Oxford, Mansfield Road, Oxford OX1 3QT, United Kingdom.
Lei M; From the Department of Pharmacology, University of Oxford, Mansfield Road, Oxford OX1 3QT, United Kingdom.
Sitsapesan R; From the Department of Pharmacology, University of Oxford, Mansfield Road, Oxford OX1 3QT, United Kingdom.
Galione A; From the Department of Pharmacology, University of Oxford, Mansfield Road, Oxford OX1 3QT, United Kingdom.
Terrar DA; From the Department of Pharmacology, University of Oxford, Mansfield Road, Oxford OX1 3QT, United Kingdom.

J Biol Chem ; 292(32): 13243-13257, 2017 08 11.

Article en En | MEDLINE | ID: mdl-28539361

Asunto(s)

ADP-Ribosil Ciclasa 1/metabolismo; Señalización del Calcio; ADP-Ribosa Cíclica/metabolismo; Glicoproteínas de Membrana/metabolismo; Miocitos Cardíacos/metabolismo; NADP/análogos & derivados; Retículo Sarcoplasmático/metabolismo; ADP-Ribosil Ciclasa 1/antagonistas & inhibidores; Agonistas Adrenérgicos beta/farmacología; Animales; Antiarrítmicos/química; Antiarrítmicos/metabolismo; Antiarrítmicos/farmacología; Señalización del Calcio/efectos de los fármacos; Permeabilidad de la Membrana Celular/efectos de los fármacos; Células Cultivadas; Detergentes/farmacología; Inhibidores Enzimáticos/farmacología; Corazón/efectos de los fármacos; Técnicas In Vitro; Masculino; Glicoproteínas de Membrana/antagonistas & inhibidores; Ratones Endogámicos C57BL; Ratones Noqueados; Simulación del Acoplamiento Molecular; Contracción Miocárdica/efectos de los fármacos; Miocitos Cardíacos/citología; Miocitos Cardíacos/efectos de los fármacos; NADP/metabolismo; Transporte de Proteínas/efectos de los fármacos; Conejos; Retículo Sarcoplasmático/efectos de los fármacos; Retículo Sarcoplasmático/enzimología; Análisis de la Célula Individual

Palabras clave

CD38; Ca2+; cardiac arrhythmia; cardiac hypertrophy; cyclic ADP-ribose (cADPR); heart; lysosomes; nicotinic acid adenine dinucleotide phosphate (NAADP); sarcoplasmic reticulum (SR); ß-adrenoceptor

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Retículo Sarcoplasmático / Glicoproteínas de Membrana / Señalización del Calcio / Miocitos Cardíacos / ADP-Ribosa Cíclica / ADP-Ribosil Ciclasa 1 / NADP Límite: Animals Idioma: En Revista: J Biol Chem Año: 2017 Tipo del documento: Article País de afiliación: Reino Unido

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