Effective chemomobilization with etoposide and cytarabine (EC regimen) in lymphoma patients: a single-center, retrospective, observational study.
Jpn J Clin Oncol
; 47(9): 820-825, 2017 09 01.
Article
en En
| MEDLINE
| ID: mdl-28541555
ABSTRACT
Objective:
Autologous stem cell transplantation is an important strategy for patients with relapsed or refractory lymphoma. Although various regimens for peripheral blood stem cell collection have been used, the optimal regimen has not yet been established. We aimed to evaluate the mobilization efficacy and safety of the regimen consisted of etoposide and cytarabine (EC regimen).Methods:
We retrospectively analyzed the clinical data of 46 lymphoma patients who received peripheral blood stem cell mobilization with the EC regimen [etoposide (100 mg/m2/day, days 1-4) and cytarabine (100 mg/m2/day, days 1-4)] at Toyohashi municipal hospital from 2004 to 2013.Results:
The median age of the patients was 55 years. The most common underlying diseases were diffuse large B-cell lymphoma (46%) and follicular lymphoma (26%). Three-quarters of patients were in their second complete or partial remission. The median total number of collected CD34+ cells was 10.6 × 106 kg-1. Forty-two patients (91%) yielded at least 2 × 106 kg-1 CD34+ cells within a median of 2 apheresis days, and 33 patients (72%) achieved it with only one apheresis. Successful mobilization was observed in five of six patients who failed to mobilize previously. Although febrile neutropenia occurred in 22 patients (48%), no fatal infection was observed.Conclusion:
The EC regimen was highly effective in lymphoma patients, including patients who mobilized poorly with other regimens.Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Trasplante Autólogo
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Linfoma de Células B Grandes Difuso
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Trasplante de Células Madre Hematopoyéticas
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Acondicionamiento Pretrasplante
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Movilización de Célula Madre Hematopoyética
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Citarabina
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Etopósido
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Antimetabolitos Antineoplásicos
Tipo de estudio:
Observational_studies
Límite:
Adolescent
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
Jpn J Clin Oncol
Año:
2017
Tipo del documento:
Article
País de afiliación:
Japón