Inhibition of Escherichia coli H+-ATPase by venturicidin, oligomycin and ossamycin.
Biochim Biophys Acta
; 807(3): 238-44, 1985 May 31.
Article
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| MEDLINE
| ID: mdl-2859888
ABSTRACT
The antibiotics venturicidin, oligomycin and ossamycin were investigated as potential inhibitors of the Escherichia coli H+-ATPase. It was found that venturicidin strongly inhibited ATP-driven proton transport and ATP hydrolysis, while oligomycin weakly inhibited these functions. Inhibition of the H+-ATPase by venturicidin and oligomycin was correlated with inhibition of F0-mediate proton transport. Both inhibitors were found to interfere with the covalent reaction between dicyclohexyl[14C]carbodiimide and the F0 subunit c (uncE protein). Ossamycin had no direct inhibitory effect on E. coli F0 or F1; rather, it was found to uncouple ATP hydrolysis from proton transport.
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Banco de datos:
MEDLINE
Asunto principal:
Oligomicinas
/
Venturicidinas
/
ATPasas de Translocación de Protón
/
Macrólidos
/
Lactonas
/
Antibacterianos
Idioma:
En
Revista:
Biochim Biophys Acta
Año:
1985
Tipo del documento:
Article