Elevated sodium leads to the increased expression of HSP60 and induces apoptosis in HUVECs.
PLoS One
; 12(6): e0179383, 2017.
Article
en En
| MEDLINE
| ID: mdl-28604836
ABSTRACT
Atherosclerosis is the leading cause of death in the world. We have previously shown that expression of heat shock protein 60 (HSP60) on the surface of endothelial cells is the main cause of initiating the disease as it acts as a T cell auto-antigen and can be triggered by classical atherosclerosis risk factors, such as infection (e.g. Chlamydia pneumoniae), chemical stress (smoking, oxygen radicals, drugs), physical insult (heat, shear blood flow) and inflammation (inflammatory cytokines, lipopolysaccharide, oxidized low density lipoprotein, advanced glycation end products). In the present study, we show that increasing levels of sodium chloride can also induce an increase in intracellular and surface expression of HSP60 protein in human umbilical vein endothelial cells. In addition, we found that elevated sodium induces apoptosis.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Sodio
/
Regulación de la Expresión Génica
/
Apoptosis
/
Chaperonina 60
/
Células Endoteliales de la Vena Umbilical Humana
Tipo de estudio:
Risk_factors_studies
Límite:
Humans
Idioma:
En
Revista:
PLoS One
Asunto de la revista:
CIENCIA
/
MEDICINA
Año:
2017
Tipo del documento:
Article
País de afiliación:
Austria