Map4k4 impairs energy metabolism in endothelial cells and promotes insulin resistance in obesity.

Roth Flach, Rachel J; DiStefano, Marina T; Danai, Laura V; Senol-Cosar, Ozlem; Yawe, Joseph C; Kelly, Mark; Garcia Menendez, Lorena; Czech, Michael P

Roth Flach, Rachel J; DiStefano, Marina T; Danai, Laura V; Senol-Cosar, Ozlem; Yawe, Joseph C; Kelly, Mark; Garcia Menendez, Lorena; Czech, Michael P.

Afiliación

Roth Flach RJ; Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts Rachel.Rothflach@pfizer.com.
DiStefano MT; Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts Rachel.Rothflach@pfizer.com.
Danai LV; Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts.
Senol-Cosar O; Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts.
Yawe JC; Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts.
Kelly M; Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts.
Garcia Menendez L; Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts.
Czech MP; Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts.

Am J Physiol Endocrinol Metab ; 313(3): E303-E313, 2017 09 01.

Article en En | MEDLINE | ID: mdl-28611026

Asunto(s)

Aterosclerosis/genética; Ascitis Quilosa/genética; Células Endoteliales/metabolismo; Metabolismo Energético/genética; Resistencia a la Insulina/genética; Linfangiogénesis/genética; Obesidad/genética; Proteínas Serina-Treonina Quinasas/genética; Tejido Adiposo/citología; Tejido Adiposo/metabolismo; Animales; Aterosclerosis/metabolismo; Glucemia/metabolismo; Senescencia Celular/genética; Citometría de Flujo; Prueba de Tolerancia a la Glucosa; Linfocitos; Ratones; Ratones Noqueados; Músculo Esquelético/irrigación sanguínea; Neovascularización Fisiológica/genética; Obesidad/metabolismo; Reacción en Cadena en Tiempo Real de la Polimerasa; Quinasa de Factor Nuclear kappa B

Palabras clave

MAP4K4; endothelial; inflammation; lymphatic; obesity

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Resistencia a la Insulina / Ascitis Quilosa / Proteínas Serina-Treonina Quinasas / Células Endoteliales / Linfangiogénesis / Metabolismo Energético / Aterosclerosis / Obesidad Límite: Animals Idioma: En Revista: Am J Physiol Endocrinol Metab Asunto de la revista: ENDOCRINOLOGIA / FISIOLOGIA / METABOLISMO Año: 2017 Tipo del documento: Article

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