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Development of Efficient Chemistry to Generate Site-Specific Disulfide-Linked Protein- and Peptide-Payload Conjugates: Application to THIOMAB Antibody-Drug Conjugates.
Sadowsky, Jack D; Pillow, Thomas H; Chen, Jinhua; Fan, Fang; He, Changrong; Wang, Yanli; Yan, Gang; Yao, Hui; Xu, Zijin; Martin, Shanique; Zhang, Donglu; Chu, Phillip; Dela Cruz-Chuh, Josefa; O'Donohue, Aimee; Li, Guangmin; Del Rosario, Geoffrey; He, Jintang; Liu, Luna; Ng, Carl; Su, Dian; Lewis Phillips, Gail D; Kozak, Katherine R; Yu, Shang-Fan; Xu, Keyang; Leipold, Douglas; Wai, John.
Afiliación
  • Sadowsky JD; Genentech, Inc. , 1 DNA Way, South San Francisco, California 94080, United States.
  • Pillow TH; Genentech, Inc. , 1 DNA Way, South San Francisco, California 94080, United States.
  • Chen J; WuXi AppTec Co., Ltd , 288 Fute Zhong Road, Waigaoqiao Free Trade Zone, Shanghai 200131, PR China.
  • Fan F; WuXi AppTec Co., Ltd , 288 Fute Zhong Road, Waigaoqiao Free Trade Zone, Shanghai 200131, PR China.
  • He C; WuXi AppTec Co., Ltd , 288 Fute Zhong Road, Waigaoqiao Free Trade Zone, Shanghai 200131, PR China.
  • Wang Y; WuXi AppTec Co., Ltd , 288 Fute Zhong Road, Waigaoqiao Free Trade Zone, Shanghai 200131, PR China.
  • Yan G; WuXi AppTec Co., Ltd , 288 Fute Zhong Road, Waigaoqiao Free Trade Zone, Shanghai 200131, PR China.
  • Yao H; WuXi AppTec Co., Ltd , 288 Fute Zhong Road, Waigaoqiao Free Trade Zone, Shanghai 200131, PR China.
  • Xu Z; WuXi AppTec Co., Ltd , 288 Fute Zhong Road, Waigaoqiao Free Trade Zone, Shanghai 200131, PR China.
  • Martin S; Genentech, Inc. , 1 DNA Way, South San Francisco, California 94080, United States.
  • Zhang D; Genentech, Inc. , 1 DNA Way, South San Francisco, California 94080, United States.
  • Chu P; Genentech, Inc. , 1 DNA Way, South San Francisco, California 94080, United States.
  • Dela Cruz-Chuh J; Genentech, Inc. , 1 DNA Way, South San Francisco, California 94080, United States.
  • O'Donohue A; Genentech, Inc. , 1 DNA Way, South San Francisco, California 94080, United States.
  • Li G; Genentech, Inc. , 1 DNA Way, South San Francisco, California 94080, United States.
  • Del Rosario G; Genentech, Inc. , 1 DNA Way, South San Francisco, California 94080, United States.
  • He J; Genentech, Inc. , 1 DNA Way, South San Francisco, California 94080, United States.
  • Liu L; Genentech, Inc. , 1 DNA Way, South San Francisco, California 94080, United States.
  • Ng C; Genentech, Inc. , 1 DNA Way, South San Francisco, California 94080, United States.
  • Su D; Genentech, Inc. , 1 DNA Way, South San Francisco, California 94080, United States.
  • Lewis Phillips GD; Genentech, Inc. , 1 DNA Way, South San Francisco, California 94080, United States.
  • Kozak KR; Genentech, Inc. , 1 DNA Way, South San Francisco, California 94080, United States.
  • Yu SF; Genentech, Inc. , 1 DNA Way, South San Francisco, California 94080, United States.
  • Xu K; Genentech, Inc. , 1 DNA Way, South San Francisco, California 94080, United States.
  • Leipold D; Genentech, Inc. , 1 DNA Way, South San Francisco, California 94080, United States.
  • Wai J; WuXi AppTec Co., Ltd , 288 Fute Zhong Road, Waigaoqiao Free Trade Zone, Shanghai 200131, PR China.
Bioconjug Chem ; 28(8): 2086-2098, 2017 08 16.
Article en En | MEDLINE | ID: mdl-28636382
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Péptidos / Ingeniería de Proteínas / Inmunoconjugados / Cisteína / Disulfuros Límite: Animals / Humans Idioma: En Revista: Bioconjug Chem Asunto de la revista: BIOQUIMICA Año: 2017 Tipo del documento: Article País de afiliación: Estados Unidos
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Péptidos / Ingeniería de Proteínas / Inmunoconjugados / Cisteína / Disulfuros Límite: Animals / Humans Idioma: En Revista: Bioconjug Chem Asunto de la revista: BIOQUIMICA Año: 2017 Tipo del documento: Article País de afiliación: Estados Unidos