Influence of a Basic Side Chain on the Properties of Hypoxia-Selective Nitro Analogues of the Duocarmycins: Demonstration of Substantial Anticancer Activity in Combination with Irradiation or Chemotherapy.

Tercel, Moana; Lee, Ho H; Mehta, Sunali Y; Youte Tendoung, Jean-Jacques; Bai, Sally Y; Liyanage, H D Sarath; Pruijn, Frederik B

Tercel, Moana; Lee, Ho H; Mehta, Sunali Y; Youte Tendoung, Jean-Jacques; Bai, Sally Y; Liyanage, H D Sarath; Pruijn, Frederik B.

Afiliación

Tercel M; Auckland Cancer Society Research Centre, Faculty of Medical and Health Sciences, The University of Auckland , Private Bag 92019, Auckland 1142, New Zealand.
Lee HH; Auckland Cancer Society Research Centre, Faculty of Medical and Health Sciences, The University of Auckland , Private Bag 92019, Auckland 1142, New Zealand.
Mehta SY; Auckland Cancer Society Research Centre, Faculty of Medical and Health Sciences, The University of Auckland , Private Bag 92019, Auckland 1142, New Zealand.
Youte Tendoung JJ; Auckland Cancer Society Research Centre, Faculty of Medical and Health Sciences, The University of Auckland , Private Bag 92019, Auckland 1142, New Zealand.
Bai SY; Auckland Cancer Society Research Centre, Faculty of Medical and Health Sciences, The University of Auckland , Private Bag 92019, Auckland 1142, New Zealand.
Liyanage HDS; Auckland Cancer Society Research Centre, Faculty of Medical and Health Sciences, The University of Auckland , Private Bag 92019, Auckland 1142, New Zealand.
Pruijn FB; Auckland Cancer Society Research Centre, Faculty of Medical and Health Sciences, The University of Auckland , Private Bag 92019, Auckland 1142, New Zealand.

J Med Chem ; 60(13): 5834-5856, 2017 07 13.

Article en En | MEDLINE | ID: mdl-28644035

Asunto(s)

Antineoplásicos/química; Antineoplásicos/uso terapéutico; Indoles/química; Indoles/uso terapéutico; Neoplasias Ováricas/tratamiento farmacológico; Ovario/efectos de los fármacos; Animales; Antineoplásicos/farmacología; Hipoxia de la Célula/efectos de los fármacos; Línea Celular Tumoral; Terapia Combinada; Ensayos de Selección de Medicamentos Antitumorales; Duocarmicinas; Femenino; Humanos; Indoles/farmacología; Ratones; Ratones Desnudos; Nitrocompuestos/química; Nitrocompuestos/farmacología; Nitrocompuestos/uso terapéutico; Neoplasias Ováricas/patología; Neoplasias Ováricas/radioterapia; Ovario/patología; Ovario/efectos de la radiación; Pirrolidinonas/química; Pirrolidinonas/farmacología; Pirrolidinonas/uso terapéutico

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Neoplasias Ováricas / Ovario / Indoles / Antineoplásicos Límite: Animals / Female / Humans Idioma: En Revista: J Med Chem Asunto de la revista: QUIMICA Año: 2017 Tipo del documento: Article País de afiliación: Nueva Zelanda

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