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Prophylactic Treatment with VT-1161 Protects Immunosuppressed Mice from Rhizopus arrhizus var. arrhizus Infection.
Gebremariam, Teclegiorgis; Alkhazraji, Sondus; Lin, Lin; Wiederhold, Nathan P; Garvey, Edward P; Hoekstra, William J; Schotzinger, Robert J; Patterson, Thomas F; Filler, Scott G; Ibrahim, Ashraf S.
Afiliación
  • Gebremariam T; Division of Infectious Diseases, Los Angeles Biomedical Research Institute at Harbor-University of California Los Angeles (UCLA) Medical Center and St. John's Cardiovascular Research Center, Torrance, California, USA.
  • Alkhazraji S; Division of Infectious Diseases, Los Angeles Biomedical Research Institute at Harbor-University of California Los Angeles (UCLA) Medical Center and St. John's Cardiovascular Research Center, Torrance, California, USA.
  • Lin L; Division of Infectious Diseases, Los Angeles Biomedical Research Institute at Harbor-University of California Los Angeles (UCLA) Medical Center and St. John's Cardiovascular Research Center, Torrance, California, USA.
  • Wiederhold NP; David Geffen School of Medicine at UCLA, Los Angeles, California, USA.
  • Garvey EP; University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA.
  • Hoekstra WJ; Viamet Pharmaceuticals, Inc., Durham, North Carolina, USA.
  • Schotzinger RJ; Viamet Pharmaceuticals, Inc., Durham, North Carolina, USA.
  • Patterson TF; Viamet Pharmaceuticals, Inc., Durham, North Carolina, USA.
  • Filler SG; University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA.
  • Ibrahim AS; South Texas Veterans Health Care System, San Antonio, Texas, USA.
Antimicrob Agents Chemother ; 61(9)2017 09.
Article en En | MEDLINE | ID: mdl-28652241
ABSTRACT
We compared prophylactic or continuous therapy with the investigational drug VT-1161 to that with posaconazole in treating murine mucormycosis due to Rhizopus arrhizus var. arrhizus In the prophylaxis studies, only VT-1161 resulted in improved survival and lowered tissue fungal burden of immunosuppressed infected mice. In the continuous therapy, VT-1161 outperformed posaconazole in prolonging mouse survival time despite its comparable effect in lowering tissue fungal burden. These results support the further development of VT-1161 against mucormycosis.
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Piridinas / Rhizopus / Tetrazoles / Sustancias Protectoras / Antifúngicos Límite: Animals Idioma: En Revista: Antimicrob Agents Chemother Año: 2017 Tipo del documento: Article País de afiliación: Estados Unidos
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Piridinas / Rhizopus / Tetrazoles / Sustancias Protectoras / Antifúngicos Límite: Animals Idioma: En Revista: Antimicrob Agents Chemother Año: 2017 Tipo del documento: Article País de afiliación: Estados Unidos