Structurally Diverse Diterpenoids from Isodon scoparius and Their Bioactivity.
J Nat Prod
; 80(7): 2026-2036, 2017 07 28.
Article
en En
| MEDLINE
| ID: mdl-28654256
ABSTRACT
Fourteen new diterpenoids (1-14) based on four skeletal types and two known analogues (15 and 16) were isolated from the aerial parts of Isodon scoparius. Compound 2 is the first ent-kaurane diterpenoid featuring a 1,11-ether bridge, and the structures of these new compounds were established mainly by NMR and MS methods. The absolute configurations of 1 and 5 and the relative configuration of 3 were determined using single-crystal X-ray diffraction. The absolute configuration of 14 was determined by comparison of the experimental and calculated electronic circular dichroism spectra. Compounds 1, 4, and 15 were active against five human tumor cell lines (HL-60, SMMC-7721, A-549, MCF-7, and SW-480), and they also inhibited NO production in LPS-stimulated RAW264.7 cells, with IC50 values of 1.0, 3.1, and 1.8 µM, respectively.
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1
Banco de datos:
MEDLINE
Asunto principal:
Isodon
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Componentes Aéreos de las Plantas
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Diterpenos de Tipo Kaurano
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Antineoplásicos Fitogénicos
Límite:
Humans
Idioma:
En
Revista:
J Nat Prod
Año:
2017
Tipo del documento:
Article