Implications of Antimicrobial Combinations in Complex Wound Biofilms Containing Fungi.
Antimicrob Agents Chemother
; 61(9)2017 09.
Article
en En
| MEDLINE
| ID: mdl-28696230
ABSTRACT
Diabetic foot ulcer treatment currently focuses on targeting bacterial biofilms, while dismissing fungi. To investigate this, we used an in vitro biofilm model containing bacteria and fungi, reflective of the wound environment, to test the impact of antimicrobials. Here we showed that while monotreatment approaches influenced biofilm composition, this had no discernible effect on overall quantity. Only by combining bacterium- and fungus-specific antibiotics were we able to decrease the biofilm bioburden, irrespective of composition.
Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Úlcera del Pie
/
Pie Diabético
/
Biopelículas
/
Antibacterianos
/
Antifúngicos
Límite:
Humans
Idioma:
En
Revista:
Antimicrob Agents Chemother
Año:
2017
Tipo del documento:
Article
País de afiliación:
Reino Unido