The super sickling haemoglobin HbS-Oman: a study of red cell sickling, K<sup>+</sup> permeability and associations with disease severity in patients heterozygous for HbA and HbS-Oman (HbA/S-Oman genotype).

Al Balushi, Halima W M; Wali, Yasser; Al Awadi, Maha; Al-Subhi, Taimoora; Rees, David C; Brewin, John N; Hannemann, Anke; Gibson, John S

The super sickling haemoglobin HbS-Oman: a study of red cell sickling, K⁺ permeability and associations with disease severity in patients heterozygous for HbA and HbS-Oman (HbA/S-Oman genotype).

Al Balushi, Halima W M; Wali, Yasser; Al Awadi, Maha; Al-Subhi, Taimoora; Rees, David C; Brewin, John N; Hannemann, Anke; Gibson, John S.

Afiliación

Al Balushi HWM; Department of Veterinary Medicine, University of Cambridge, Cambridge, UK.
Wali Y; Department of Child Health, Sultan Qaboos University, Muscat, Oman.
Al Awadi M; Department of Genetics, Sultan Qaboos University, Muscat, Oman.
Al-Subhi T; Department of Child Health, Sultan Qaboos University, Muscat, Oman.
Rees DC; Department of Paediatric Haematology, King's College Hospital, King's College London School of Medicine, London, UK.
Brewin JN; Department of Paediatric Haematology, King's College Hospital, King's College London School of Medicine, London, UK.
Hannemann A; Department of Veterinary Medicine, University of Cambridge, Cambridge, UK.
Gibson JS; Department of Veterinary Medicine, University of Cambridge, Cambridge, UK.

Br J Haematol ; 179(2): 256-265, 2017 10.

Article en En | MEDLINE | ID: mdl-28699687

Asunto(s)

Eritrocitos Anormales/metabolismo; Hemoglobina A/genética; Hemoglobinas Anormales/genética; Heterocigoto; Canales de Potasio de Conductancia Intermedia Activados por el Calcio/metabolismo; Potasio/metabolismo; Talasemia alfa; Adolescente; Adulto; Anciano; Niño; Preescolar; Femenino; Humanos; Canales de Potasio de Conductancia Intermedia Activados por el Calcio/genética; Masculino; Persona de Mediana Edad; Permeabilidad; Índice de Severidad de la Enfermedad; Talasemia alfa/genética; Talasemia alfa/metabolismo

Palabras clave

HbS-Oman; K+ permeability; sickle cell disease; sickling; α thalassaeamia

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Potasio / Hemoglobina A / Hemoglobinas Anormales / Talasemia alfa / Eritrocitos Anormales / Canales de Potasio de Conductancia Intermedia Activados por el Calcio / Heterocigoto Tipo de estudio: Risk_factors_studies Límite: Adolescent / Adult / Aged / Child / Child, preschool / Female / Humans / Male / Middle aged Idioma: En Revista: Br J Haematol Año: 2017 Tipo del documento: Article País de afiliación: Reino Unido

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