Beta2-adrenergic stimulation increases energy expenditure at rest, but not during submaximal exercise in active overweight men.
Eur J Appl Physiol
; 117(9): 1907-1915, 2017 Sep.
Article
en En
| MEDLINE
| ID: mdl-28702809
ABSTRACT
PURPOSE:
ß2-Agonists have been proposed as weight-loss treatment, because they elevate energy expenditure. However, it is unknown what effect ß2-agonists have on energy expenditure in overweight individuals. Furthermore, the influence of ß2-agonist R- and S-enantiomer ratio for the increased energy expenditure is insufficiently explored.METHODS:
Nineteen males were included in the study of which 14 completed. Subjects were 31.6 (±3.5) years [mean (±95% CI)] and had a fat percentage of 22.7 (±2.1)%. On separate days, subjects received either placebo or inhaled racemic (rac-) formoterol (2 × 27 µg). After an overnight fast, energy expenditure and substrate oxidation were estimated by indirect calorimetry at rest and during submaximal exercise. Plasma (R,R)- and (S,S)-formoterol enantiomer levels were measured by ultra-performance liquid chromatograph-mass spectrometry.RESULTS:
At rest, energy expenditure and fat oxidation were 12% (P ≤ 0.001) and 38% (P = 0.006) higher for rac-formoterol than placebo. Systemic (R,R)(S,S) formoterol ratio was correlated with change in energy expenditure at rest in response to rac-formoterol (r = 0.63, P = 0.028), whereas no association was observed between fat percentage and rac-formoterol-induced change in energy expenditure. During exercise, energy expenditure was not different between treatments, although carbohydrate oxidation was 15% higher (P = 0.021) for rac-formoterol than placebo. Rac-formoterol-induced shift in substrate choice from rest to exercise was related to plasma ln-rac-formoterol concentrations (r = 0.75, P = 0.005).CONCLUSION:
Selective ß2-adrenoceptor agonism effectively increases metabolic rate and fat oxidation in overweight individuals. The potential for weight loss induced by ß2-agonists may be greater for R-enantiopure formulations.Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Ejercicio Físico
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Metabolismo Energético
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Sobrepeso
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Agonistas de Receptores Adrenérgicos beta 2
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Fumarato de Formoterol
Tipo de estudio:
Clinical_trials
/
Health_economic_evaluation
Límite:
Adult
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Humans
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Male
Idioma:
En
Revista:
Eur J Appl Physiol
Asunto de la revista:
FISIOLOGIA
Año:
2017
Tipo del documento:
Article
País de afiliación:
Dinamarca