Epigenetic suppression of human telomerase (<i>hTERT</i>) is mediated by the metastasis suppressor NME2 in a G-quadruplex-dependent fashion.

Saha, Dhurjhoti; Singh, Ankita; Hussain, Tabish; Srivastava, Vivek; Sengupta, Suman; Kar, Anirban; Dhapola, Parashar; Dhople, Vishnu; Ummanni, Ramesh; Chowdhury, Shantanu

Epigenetic suppression of human telomerase (hTERT) is mediated by the metastasis suppressor NME2 in a G-quadruplex-dependent fashion.

Saha, Dhurjhoti; Singh, Ankita; Hussain, Tabish; Srivastava, Vivek; Sengupta, Suman; Kar, Anirban; Dhapola, Parashar; Dhople, Vishnu; Ummanni, Ramesh; Chowdhury, Shantanu.

Afiliación

Saha D; From the Genomics and Molecular Medicine Unit.
Singh A; Academy of Scientific & Innovative Research (AcSIR), CSIR-Institute of Genomics and Integrative Biology, Council of Scientific and Industrial Research (CSIR), Mathura Road, New Delhi 110025, India and.
Hussain T; From the Genomics and Molecular Medicine Unit.
Srivastava V; Academy of Scientific & Innovative Research (AcSIR), CSIR-Institute of Genomics and Integrative Biology, Council of Scientific and Industrial Research (CSIR), Mathura Road, New Delhi 110025, India and.
Sengupta S; From the Genomics and Molecular Medicine Unit.
Kar A; From the Genomics and Molecular Medicine Unit.
Dhapola P; From the Genomics and Molecular Medicine Unit.
Dhople V; From the Genomics and Molecular Medicine Unit.
Ummanni R; G.N.R. Knowledge Centre for Genome Informatics, and.
Chowdhury S; Academy of Scientific & Innovative Research (AcSIR), CSIR-Institute of Genomics and Integrative Biology, Council of Scientific and Industrial Research (CSIR), Mathura Road, New Delhi 110025, India and.

J Biol Chem ; 292(37): 15205-15215, 2017 09 15.

Article en En | MEDLINE | ID: mdl-28717007

Asunto(s)

Carcinoma/metabolismo; Represión Epigenética; Fibrosarcoma/metabolismo; G-Cuádruplex; Nucleósido Difosfato Quinasas NM23/metabolismo; Regiones Promotoras Genéticas; Telomerasa/metabolismo; Sustitución de Aminoácidos; Carcinoma/enzimología; Carcinoma/patología; Línea Celular Tumoral; Células Cultivadas; Inmunoprecipitación de Cromatina; Fibrosarcoma/enzimología; Fibrosarcoma/patología; Genes Reporteros; Histona Demetilasas/química; Histona Demetilasas/metabolismo; Humanos; Mutagénesis Sitio-Dirigida; Nucleósido Difosfato Quinasas NM23/antagonistas & inhibidores; Nucleósido Difosfato Quinasas NM23/química; Nucleósido Difosfato Quinasas NM23/genética; Proteínas de Neoplasias/antagonistas & inhibidores; Proteínas de Neoplasias/química; Proteínas de Neoplasias/genética; Proteínas de Neoplasias/metabolismo; Mutación Puntual; Multimerización de Proteína; Interferencia de ARN; Proteínas Recombinantes/química; Proteínas Recombinantes/metabolismo; Proteínas Represoras/antagonistas & inhibidores; Proteínas Represoras/química; Proteínas Represoras/genética; Proteínas Represoras/metabolismo; Telomerasa/antagonistas & inhibidores; Telomerasa/genética

Palabras clave

G-quadruplex; NME2; REST repressor complex; chromatin modification; epigenetics; telomerase reverse transcriptase (TERT); transcription regulation

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Carcinoma / Regiones Promotoras Genéticas / Telomerasa / Nucleósido Difosfato Quinasas NM23 / G-Cuádruplex / Fibrosarcoma / Represión Epigenética Idioma: En Revista: J Biol Chem Año: 2017 Tipo del documento: Article

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