Colorectal cancer and inflammatory bowel diseases: effects of diet and antioxidants.
J Biol Regul Homeost Agents
; 31(3): 791-795, 2017.
Article
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| MEDLINE
| ID: mdl-28726358
ABSTRACT
It is well established that oxidative stress is common in inflammatory bowel diseases (IBDs). Accordingly, antioxidants are recommended for treatment. The aim of this study is to compare the effects of antioxidants contained in the various types of tea on symptoms and evolution of IBD and colorectal cancer (CRC). Analysis of the literature revealed that the theaflavin-3, 30-digallate (TFDG) contained in black tea, and epigallocatechin-3-O-gallate (EGCG) contained in green tea have protective effects against oxidative stress. Moreover, these substances are involved in many biochemical processes responsible for inflammation and proliferation of cancer cells. It is documented that both TFDG and EGCG are able to reduce inflammatory phenomena and symptoms associated with IBD, as well as to reduce the proliferation of CRC cells. Most studies are performed in vitro or in experimental animal models. It is, therefore, advisable to formulate studies that could be carried out on humans or human samples, in order to develop the appropriate therapeutic strategies.
Palabras clave
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Banco de datos:
MEDLINE
Asunto principal:
Té
/
Neoplasias Colorrectales
/
Enfermedades Inflamatorias del Intestino
/
Catequina
/
Biflavonoides
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Dieta
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Ácido Gálico
/
Antioxidantes
Límite:
Animals
/
Humans
Idioma:
En
Revista:
J Biol Regul Homeost Agents
Asunto de la revista:
BIOLOGIA
/
BIOQUIMICA
Año:
2017
Tipo del documento:
Article
País de afiliación:
Italia