Effect of the anticonvulsant denzimol on the disposition of diazepam in the rat.
J Pharm Pharmacol
; 38(6): 469-72, 1986 Jun.
Article
en En
| MEDLINE
| ID: mdl-2873226
ABSTRACT
The influence of denzimol, a new imidazole derivative with anticonvulsant properties, on the disposition of diazepam (1 mg kg-1) was investigated in the rat. Denzimol pretreatment significantly increased plasma and brain concentrations of the benzodiazepine, consistent with reduced total clearance. The results suggest that the increase of diazepam brain concentrations by denzimol may produce enhancement of diazepam activity in the rat.
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Banco de datos:
MEDLINE
Asunto principal:
Diazepam
/
Imidazoles
/
Anticonvulsivantes
Límite:
Animals
Idioma:
En
Revista:
J Pharm Pharmacol
Año:
1986
Tipo del documento:
Article