Smarcal1-Mediated Fork Reversal Triggers Mre11-Dependent Degradation of Nascent DNA in the Absence of Brca2 and Stable Rad51 Nucleofilaments.

Kolinjivadi, Arun Mouli; Sannino, Vincenzo; De Antoni, Anna; Zadorozhny, Karina; Kilkenny, Mairi; Técher, Hervé; Baldi, Giorgio; Shen, Rong; Ciccia, Alberto; Pellegrini, Luca; Krejci, Lumir; Costanzo, Vincenzo

Kolinjivadi, Arun Mouli; Sannino, Vincenzo; De Antoni, Anna; Zadorozhny, Karina; Kilkenny, Mairi; Técher, Hervé; Baldi, Giorgio; Shen, Rong; Ciccia, Alberto; Pellegrini, Luca; Krejci, Lumir; Costanzo, Vincenzo.

Afiliación

Kolinjivadi AM; DNA Metabolism Laboratory, IFOM, FIRC Institute for Molecular Oncology, 20139 Milan, Italy.
Sannino V; DNA Metabolism Laboratory, IFOM, FIRC Institute for Molecular Oncology, 20139 Milan, Italy.
De Antoni A; DNA Metabolism Laboratory, IFOM, FIRC Institute for Molecular Oncology, 20139 Milan, Italy.
Zadorozhny K; Department of Biology, Masaryk University, Brno 625 00, Czech Republic.
Kilkenny M; Department of Biochemistry, Tennis Court Road, University of Cambridge, Cambridge CB2 1GA, UK.
Técher H; DNA Metabolism Laboratory, IFOM, FIRC Institute for Molecular Oncology, 20139 Milan, Italy.
Baldi G; DNA Metabolism Laboratory, IFOM, FIRC Institute for Molecular Oncology, 20139 Milan, Italy.
Shen R; Department of Biochemistry, Tennis Court Road, University of Cambridge, Cambridge CB2 1GA, UK.
Ciccia A; Department of Genetics and Development, Columbia University Irving Medical Center, New York, NY 10032, USA.
Pellegrini L; Department of Biochemistry, Tennis Court Road, University of Cambridge, Cambridge CB2 1GA, UK. Electronic address: lp212@cam.ac.uk.
Krejci L; Department of Biology, Masaryk University, Brno 625 00, Czech Republic; National Centre for Biomolecular Research, Masaryk University, Brno 625 00, Czech Republic; International Clinical Research Center, St. Anne's University Hospital, Brno 656 91, Czech Republic. Electronic address: lkrejci@chemi.m
Costanzo V; DNA Metabolism Laboratory, IFOM, FIRC Institute for Molecular Oncology, 20139 Milan, Italy. Electronic address: vincenzo.costanzo@ifom.eu.

Mol Cell ; 67(5): 867-881.e7, 2017 Sep 07.

Article en En | MEDLINE | ID: mdl-28757209

Asunto(s)

Proteína BRCA2/metabolismo; Replicación del ADN; ADN/biosíntesis; Recombinasa Rad51/metabolismo; Proteínas de Xenopus/metabolismo; Xenopus laevis/metabolismo; Animales; Proteína BRCA2/genética; Sitios de Unión; ADN/genética; ADN Helicasas/genética; ADN Helicasas/metabolismo; ADN Polimerasa I/metabolismo; ADN Polimerasa III/metabolismo; Proteínas de Unión al ADN/genética; Proteínas de Unión al ADN/metabolismo; Endodesoxirribonucleasas/genética; Endodesoxirribonucleasas/metabolismo; Exodesoxirribonucleasas/genética; Exodesoxirribonucleasas/metabolismo; Femenino; Inestabilidad Genómica; Humanos; Proteína Homóloga de MRE11; Masculino; Mutación; Unión Proteica; Recombinasa Rad51/genética; Origen de Réplica; Proteínas de Saccharomyces cerevisiae/genética; Proteínas de Saccharomyces cerevisiae/metabolismo; Factores de Tiempo; Proteínas de Xenopus/genética; Xenopus laevis/genética

Palabras clave

Brca2; DNA replication; Mre11; Rad51; Xenopus laevis; fork protection

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Xenopus laevis / ADN / Proteínas de Xenopus / Proteína BRCA2 / Replicación del ADN / Recombinasa Rad51 Límite: Animals / Female / Humans / Male Idioma: En Revista: Mol Cell Asunto de la revista: BIOLOGIA MOLECULAR Año: 2017 Tipo del documento: Article País de afiliación: Italia

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