Therapeutic potentials of short interfering RNAs.
Appl Microbiol Biotechnol
; 101(19): 7091-7111, 2017 Oct.
Article
en En
| MEDLINE
| ID: mdl-28791440
ABSTRACT
Short interfering RNA (siRNA) is one of the members of the family of RNA interference (RNAi). Coupled with the RNA-induced silencing complex (RISC), siRNA is able to trigger the cleavage of target RNAs which serve as a defensive system against pathogens. Meanwhile, siRNA in gene silencing opens a new avenue for the treatment of various diseases. SiRNA can effectively inhibit viral infection and replication and suppress tumorigenesis and various inflammation-associated diseases and cardiovascular diseases by inactivation of viral genes and downregulation of oncogene expression. Recently, endogenous siRNAs (endo-siRNAs) were discovered in the reproductive cells of animals which may be associated with regulation of cell division. Structural modification of siRNA enhances the delivery, specificity and efficacy and bioavailability to the target cells. There are at least five categories of siRNA delivery systems including viral vectors, lipid-based nanoparticles, peptide-based nanoparticles, polymer-based nanoparticles and inorganic small molecules like metal ions, silica and carbon. Sufficient preclinical and clinical studies supported that siRNA may be a potential medicine for targeted therapy of various diseases in the near future.
Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Silenciador del Gen
/
ARN Interferente Pequeño
/
Vectores Genéticos
Tipo de estudio:
Clinical_trials
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Appl Microbiol Biotechnol
Año:
2017
Tipo del documento:
Article
País de afiliación:
China