Effects of co-exposure to imidacloprid and gibberellic acid on redox status, kidney variables and histopathology in adult rats.
Arch Physiol Biochem
; 124(2): 175-184, 2018 May.
Article
en En
| MEDLINE
| ID: mdl-28875714
ABSTRACT
Data on the individual nephrotoxic effects of imidacloprid (IMI) and gibberellic acid (GA3) are scarce. Moreover, there is a lack of information about their combined effects on the renal tissue. Our study investigated the effects of IMI and GA3 separately or together on rats kidney. IMI (64 mg/kg bw) was given for 3 weeks by gavage either individually or in combination with GA3 (200 mg/L) via drinking water. IMI associated or no with GA3 increased the levels of kidney malondialdehyde, advanced oxidation protein products, protein carbonyls and metallothionein, plasma creatinine, urea, blood urea nitrogen and lactate dehydrogenase activity. A decline of kidney uric acid level and antioxidant status was also observed. All these changes were supported by histopathological observations. Our results highlighted the role of IMI and/or GA3-induced nephrotoxicity. Co-exposure to IMI and GA3 exhibited synergism in biochemical kidney variables and histopathology and antagonism in physical and morphological parameters.
Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Reguladores del Crecimiento de las Plantas
/
Intoxicación
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Insuficiencia Renal
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Neonicotinoides
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Giberelinas
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Insecticidas
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Riñón
/
Nitrocompuestos
Tipo de estudio:
Etiology_studies
Límite:
Animals
Idioma:
En
Revista:
Arch Physiol Biochem
Asunto de la revista:
BIOQUIMICA
/
FISIOLOGIA
Año:
2018
Tipo del documento:
Article
País de afiliación:
Túnez