Zinc oxide nanoparticle inhibits the biofilm formation of Streptococcus pneumoniae.
Antonie Van Leeuwenhoek
; 111(1): 89-99, 2018 Jan.
Article
en En
| MEDLINE
| ID: mdl-28889242
ABSTRACT
Biofilms are structured consortia of microbial cells that grow on living and non living surfaces and surround themselves with secreted polymers. Infections with bacterial biofilms have emerged as a foremost public health concern because biofilm growing cells can be highly resistant to both antibiotics and host immune defenses. Zinc oxide nanoparticles have been reported as a potential antimicrobial agent, thus, in the current study, we have evaluated the antimicrobial as well as antibiofilm activity of zinc oxide nanoparticles against the bacterium Streptococcus pneumoniae which is a significant cause of disease. Zinc oxide nanoparticles showed strong antimicrobial activity against S. pneumoniae, with an MIC value of 40 µg/ml. Biofilm inhibition of S. pneumoniae was also evaluated by performing a series of experiments such as crystal violet assay, microscopic observation, protein count, EPS secretion etc. using sub-MIC concentrations (3, 6 and 12 µg/ml) of zinc oxide nanoparticles. The results showed that the sub-MIC doses of zinc oxide nanoparticles exhibited significant anti-biofilm activity against S. pneumoniae, with maximum biofilm attenuation found at 12 µg/ml. Taken together, the results indicate that zinc oxide nanoparticles can be considered as a potential agent for the inhibition of microbial biofilms.
Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Streptococcus pneumoniae
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Óxido de Zinc
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Biopelículas
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Nanopartículas del Metal
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Antibacterianos
Idioma:
En
Revista:
Antonie Van Leeuwenhoek
Año:
2018
Tipo del documento:
Article
País de afiliación:
India