[Application of high performance liquid-ion trap mass spectrometry in analyzing saponins in sodium aescinate].
Zhongguo Zhong Yao Za Zhi
; 41(13): 2449-2454, 2016 Jul.
Article
en Zh
| MEDLINE
| ID: mdl-28905567
ABSTRACT
Sodium aescinate, which is produced from saponins of Chinese Buckeye Seed, is a prescription drug for treatment of brain edema and all kinds of swellings caused by surgery. In this article, high-performance liquid chromatography/ion trap (HPLC-IT) mass spectrometry was applied to study the characteristic ions of ten reference substances, namely escin â
a, escin â
b, isoescin â
a, isoescin â
b, aesculiside A, aesculiside B, aesculuside A, escin â
£c, escinâ
¡a and escin â
¤, which were isolated from aescinate. Furthermore, 19 saponin compounds were predicted in sodium aescinate, besides the above mentioned reference substances. The study showed that sapogenins in sodium aescinate had two structural types, namely protoaescigenin and barringenol C, and the substituent acetyl, tigloyl or angeloyl was usually located at C-21, C-22 or C-28 position. Among these predicted saponins, their sugar chains were all located at C-3 position consisting of glucose and glucuronide. This study provides experimental data for chemical constituents in sodium aescinate and scientific basis for quality and safety evaluation.
Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Saponinas
/
Triterpenos
/
Medicamentos Herbarios Chinos
Tipo de estudio:
Prognostic_studies
Idioma:
Zh
Revista:
Zhongguo Zhong Yao Za Zhi
Asunto de la revista:
FARMACOLOGIA
/
TERAPIAS COMPLEMENTARES
Año:
2016
Tipo del documento:
Article
País de afiliación:
China