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Adipose tissue content of saturated fatty acids and atrial fibrillation: A case-cohort study.
Dinesen, Pia T; Rix, Thomas A; Joensen, Albert M; Tjønneland, Anne; Lundbye-Christensen, Søren; Overvad, Kim; Schmidt, Erik B.
Afiliación
  • Dinesen PT; Department of Cardiology, Aalborg University Hospital, Aalborg, Denmark.
  • Rix TA; Department of Cardiology, Aalborg AF Study Group, Aalborg University Hospital, Aalborg, Denmark.
  • Joensen AM; Department of Cardiology, Aalborg University Hospital, Aalborg, Denmark.
  • Tjønneland A; Department of Cardiology, Aalborg University Hospital, Aalborg, Denmark.
  • Lundbye-Christensen S; Unit of Diet, Genes and Environment, Danish Cancer Society Research Center, Copenhagen, Denmark.
  • Overvad K; Department of Cardiology, Aalborg AF Study Group, Aalborg University Hospital, Aalborg, Denmark.
  • Schmidt EB; Unit of Clinical Biostatistics, Aalborg University, Aalborg, Denmark.
Eur J Clin Invest ; 47(12)2017 Dec.
Article en En | MEDLINE | ID: mdl-28906545
ABSTRACT

OBJECTIVES:

The aim of this study was to investigate the association between adipose tissue content of total saturated fatty acids including myristic (C140), palmitic (C160) and stearic (C180) acid, as a measure of exposure to saturated fatty acids and the risk of incident atrial fibrillation. MATERIALS AND

METHODS:

A total of 57 053 Danish men and women aged 50-64 years participating in the Diet, Cancer and Health cohort had an adipose tissue biopsy taken at baseline, and this was analysed for saturated fatty acids content by gas chromatography. Follow-up was registry based and in this case-cohort study we used all cases and a randomly drawn subcohort of 3500 participants representative for the entire cohort.

RESULTS:

Data were analysed using weighted Cox proportional hazards regression. During a median follow-up of 14.6 years, a total of 4722 cases of incident atrial fibrillation were diagnosed. For both men and women, no association between adipose tissue content of total saturated fatty acids and the risk of atrial fibrillation could be demonstrated.

CONCLUSION:

We did not find an association between adipose tissue content of total saturated fatty acids and the risk of incident atrial fibrillation.
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Fibrilación Atrial / Sistema de Registros / Tejido Adiposo / Ácidos Grasos Tipo de estudio: Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Aged / Female / Humans / Male / Middle aged País/Región como asunto: Europa Idioma: En Revista: Eur J Clin Invest Año: 2017 Tipo del documento: Article País de afiliación: Dinamarca

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Fibrilación Atrial / Sistema de Registros / Tejido Adiposo / Ácidos Grasos Tipo de estudio: Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Aged / Female / Humans / Male / Middle aged País/Región como asunto: Europa Idioma: En Revista: Eur J Clin Invest Año: 2017 Tipo del documento: Article País de afiliación: Dinamarca