Adipose tissue content of saturated fatty acids and atrial fibrillation: A case-cohort study.
Eur J Clin Invest
; 47(12)2017 Dec.
Article
en En
| MEDLINE
| ID: mdl-28906545
ABSTRACT
OBJECTIVES:
The aim of this study was to investigate the association between adipose tissue content of total saturated fatty acids including myristic (C140), palmitic (C160) and stearic (C180) acid, as a measure of exposure to saturated fatty acids and the risk of incident atrial fibrillation. MATERIALS ANDMETHODS:
A total of 57 053 Danish men and women aged 50-64 years participating in the Diet, Cancer and Health cohort had an adipose tissue biopsy taken at baseline, and this was analysed for saturated fatty acids content by gas chromatography. Follow-up was registry based and in this case-cohort study we used all cases and a randomly drawn subcohort of 3500 participants representative for the entire cohort.RESULTS:
Data were analysed using weighted Cox proportional hazards regression. During a median follow-up of 14.6 years, a total of 4722 cases of incident atrial fibrillation were diagnosed. For both men and women, no association between adipose tissue content of total saturated fatty acids and the risk of atrial fibrillation could be demonstrated.CONCLUSION:
We did not find an association between adipose tissue content of total saturated fatty acids and the risk of incident atrial fibrillation.Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Fibrilación Atrial
/
Sistema de Registros
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Tejido Adiposo
/
Ácidos Grasos
Tipo de estudio:
Etiology_studies
/
Incidence_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Límite:
Aged
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Female
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Humans
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Male
/
Middle aged
País/Región como asunto:
Europa
Idioma:
En
Revista:
Eur J Clin Invest
Año:
2017
Tipo del documento:
Article
País de afiliación:
Dinamarca