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Developments in the formulation and delivery of spray dried vaccines.
Kanojia, Gaurav; Have, Rimko Ten; Soema, Peter C; Frijlink, Henderik; Amorij, Jean-Pierre; Kersten, Gideon.
Afiliación
  • Kanojia G; a Intravacc (Institute for Translational Vaccinology) , Bilthoven , The Netherlands.
  • Have RT; b Department of Pharmaceutical Technology and Biopharmacy , University of Groningen , Groningen , The Netherlands.
  • Soema PC; a Intravacc (Institute for Translational Vaccinology) , Bilthoven , The Netherlands.
  • Frijlink H; a Intravacc (Institute for Translational Vaccinology) , Bilthoven , The Netherlands.
  • Amorij JP; b Department of Pharmaceutical Technology and Biopharmacy , University of Groningen , Groningen , The Netherlands.
  • Kersten G; d Virtuvax BV , Odijk , The Netherlands.
Hum Vaccin Immunother ; 13(10): 2364-2378, 2017 10 03.
Article en En | MEDLINE | ID: mdl-28925794
ABSTRACT
Spray drying is a promising method for the stabilization of vaccines, which are usually formulated as liquids. Usually, vaccine stability is improved by spray drying in the presence of a range of excipients. Unlike freeze drying, there is no freezing step involved, thus the damage related to this step is avoided. The edge of spray drying resides in its ability for particles to be engineered to desired requirements, which can be used in various vaccine delivery methods and routes. Although several spray dried vaccines have shown encouraging preclinical results, the number of vaccines that have been tested in clinical trials is limited, indicating a relatively new area of vaccine stabilization and delivery. This article reviews the current status of spray dried vaccine formulations and delivery methods. In particular it discusses the impact of process stresses on vaccine integrity, the application of excipients in spray drying of vaccines, process and formulation optimization strategies based on Design of Experiment approaches as well as opportunities for future application of spray dried vaccine powders for vaccine delivery.
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Vacunas Límite: Animals / Humans Idioma: En Revista: Hum Vaccin Immunother Año: 2017 Tipo del documento: Article País de afiliación: Países Bajos

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Vacunas Límite: Animals / Humans Idioma: En Revista: Hum Vaccin Immunother Año: 2017 Tipo del documento: Article País de afiliación: Países Bajos